Evidence map›Paper›PMID 7980002›Full record

ArticleArchives of virology1994

The S1 glycoprotein but not the N or M proteins of avian infectious bronchitis virus induces protection in vaccinated chickens.

J Ignjatovic, L Galli

Open access · bronzeAbstract read
In one paragraph

Article in Archives of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 178 citations in OpenAlex.

  1. Article
  2. Article
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  4. Avian infectious bronchitis virus (AIBV) review by continent.Frontiers in cellular and infection microbiology · 2024
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  7. Detection and isolation of QX-like infectious bronchitis virus in Japan.The Journal of veterinary medical science · 2022
    Article
  8. Review
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  12. Nanotherapeutics for treating coronavirus diseases.Journal of drug delivery science and technology · 2021
    Review
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  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

J IgnjatovicCSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Victoria, Australia.
L Galli
Australian Centre for Disease Preparedness · AUCommonwealth Scientific and Industrial Research Organisation · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The S1, N and M proteins, obtained from the nephropathogenic N1/62 strain of infectious bronchitis virus (IBV) by immunoaffinity purification with monoclonal antibodies, were used for immunization of chickens. For all three antigens multiple immunizations were necessary for induction of an antibody response. Protection of chickens vaccinated with the S1 glycoprotein against virulent challenge was demonstrated by the complete absence of virus in tracheas and kidneys of vaccinated chickens. Following four immunizations with the S1 glycoprotein 71% and 86% of chickens were protected at the level of tracheas and kidneys, respectively. Three immunizations with the S1 glycoprotein protected 70% and 10% of chickens at the level of kidney and trachea, respectively. Neither the N nor the M antigen induced protection to a virulent challenge with the nephropathogenic N1/62 strain of IBV after four immunizations. Virus neutralizing, haemagglutination inhibiting and ELISA antibodies were detected in chickens immunized with the S1 glycoprotein and inactivated N1/62 virus, however there was no correlation between the presence of any of these antibodies and protection.

Indexed as

ChickensInfectious bronchitis virusAmino Acid SequenceAnimalsAntibodies, ViralCapsidChick EmbryoCoronavirus InfectionsCoronavirus M ProteinsMembrane GlycoproteinsMolecular Sequence DataPoultry DiseasesSpike Glycoprotein, CoronavirusViral Core ProteinsViral Envelope ProteinsViral Matrix ProteinsAntibodies, ViralCoronavirus M ProteinsMembrane GlycoproteinsM protein, Avian infectious bronchitis virusSpike Glycoprotein, CoronavirusViral Core ProteinsViral Envelope ProteinsViral Matrix ProteinsViral Vaccines

Identifiers

PMID7980002
PMCPMC7087189
OpenAlexW2090006694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.