ArticleThe American journal of pathology1994
Cell behavior in the acetylaminofluorene-treated regenerating rat liver. Light and electron microscopic observations.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 83 citations in OpenAlex.
- "Small Hepatocytes" in the Liver.Cells · 2023Review
- Regenerating the liver: not so simple after all?F1000Research · 2016Review
- Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet.Hepatology (Baltimore, Md.) · 2010Article
- Hepatic progenitor cells in chronic hepatitis C: a phenomenon of older age and advanced liver disease.Virchows Archiv : an international journal of pathology · 2010Article
- Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents.Histochemistry and cell biology · 2009Article
- Intestinal metaplasia in liver of rats after partial hepatectomy and treatment with acetylaminofluorene.Cell proliferation · 2009Article
- Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro.The American journal of pathology · 2008Article
- Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury.Histochemistry and cell biology · 2007Article
- Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regeneration.Histochemistry and cell biology · 2006Article
- Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1.The American journal of pathology · 2003Article
- Hepatic microenvironment affects oval cell localization in albumin-urokinase-type plasminogen activator transgenic mice.The American journal of pathology · 2003Article
- Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver.The American journal of pathology · 2002Article
- Origin and structural evolution of the early proliferating oval cells in rat liver.The American journal of pathology · 2001Article
- Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury.The American journal of pathology · 2000Article
- Differential growth: from carcinogenesis to liver repopulation.The American journal of pathology · 2000Review
- Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response.The American journal of pathology · 2000Article
- Wound healing in the liver with particular reference to stem cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
- Bile ductular damage induced by methylene dianiline inhibits oval cell activation.The American journal of pathology · 1997Article
- Blast-like cell compartment in carcinogen-induced proliferating bile ductules.The American journal of pathology · 1996Article
- Islet cell neogenesis in the pancreas.Virchows Archiv : an international journal of pathology · 1996Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When hepatocyte regeneration is impaired, facultative stem cells and their descendants, also called oval cells, become activated and produce cell progeny that eventually differentiate. We have observed these cells in the rat liver after partial hepatectomy when the animals have been fed 2-acetylaminofluorene. Oval cells emerge from the portal areas and stain strongly with monoclonal antibodies raised against cytokeratins 8 and 19 and vimentin, the intermediate filament traditionally associated with mesenchymal cells. The majority of oval cells appeared to be part of a bile ductular reaction, manifest by their cytokeratin expression, and the bile duct injection of pigmented gelatin confirmed that these oval cells were essentially tortuous, arborizing duct-like structures (cholangioles) branched from and continuous with preexisting bile ducts. In situ hybridization studies showed that hepatocyte growth factor mRNA-expressing sinusoid lining cells were most numerous in the periportal areas during the period of ductular proliferation. At 1 week after partial hepatectomy, we observed morphological evidence of areas of in situ focal differentiation in the ductular structures, either to a columnar intestinal-type epithelia or to a hepatocyte phenotype, with abundant large mitochondria and membranous cytokeratin 8 immunoreactivity contrasting with the diffuse staining of the ductular cells. By following the fate of oval cells the authors conclude that in this model proliferated bile ductules represent the oval cell compartment capable of producing pluripotential progenitor cells.
Indexed as
Identifiers
7977643PMC1887432W194075009What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.