ArticleAmerican journal of human genetics1994
Multiple DNA variant association analysis: application to the insulin gene region in type I diabetes.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Influence of Insulin Receptor Single Nucleotide Polymorphisms on Glycaemic Control and Formation of Anti-Insulin Antibodies in Diabetes Mellitus.International journal of molecular sciences · 2022Article
- Regulation of inflammation in diabetes: From genetics to epigenomics evidence.Molecular metabolism · 2020Review
- The Genetic Profile from HLA and Non-HLA Loci Allows Identification of Atypical Type 2 Diabetes Patients.Journal of diabetes research · 2015Article
- The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.Genes and immunity · 2009Article
- Genetics of type 1 diabetes mellitus.Genes and immunity · 2002Review
- Evidence for linkage and association with reading disability on 6p21.3-22.American journal of human genetics · 2002Article
- A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.American journal of human genetics · 2001Article
- Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.American journal of human genetics · 2001Article
- Genetic predisposition to IDDM.Clinical reviews in allergy & immunology · 2000Review
- Evidence for the presence of insulin-dependent diabetes-associated alleles on the distal part of mouse chromosome 6.Genome research · 1998Article
- Non-HLA genes and the susceptibility to insulin dependent diabetes: the role of the CTLA-4 gene.Acta diabetologica · 1996Review
- Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.Diabetologia · 1996Article
- Genetic analysis of type 1 diabetes using whole genome approaches.Proceedings of the National Academy of Sciences of the United States of America · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Association and linkage studies have shown that at least one of the genetic factors involved in susceptibility to insulin-dependent diabetes mellitus (IDDM) is contained within a 4.1-kb region of the insulin gene. Sequence analysis has led to the identification of 10 DNA variants in this region that are associated with increased risk for IDDM. These variants are in strong linkage disequilibrium with each other, and previous studies have failed to distinguish between the variant(s) that cause increased susceptibility to IDDM and others that are associated with the disease because of linkage disequilibrium. To address this problem, we have undertaken a large population study of French diabetics and controls and have analyzed genotype patterns for several of the variant sites simultaneously. This has led to the identification of a subset consisting of four variants (-2733AC, -23HphI, -365VNTR, and +1140AC), at least one of which appears to be directly implicated in disease susceptibility. The multiple-DNA-variant association-analysis approach that is applied here to the problem of identifying potential susceptibility variants in IDDM is likely to be important in studies of many other multifactorial diseases.
Indexed as
Identifiers
7977386PMC1918440W1512638398What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.