ArticleAmerican journal of human genetics1994
Genetic epidemiology of vitiligo: multilocus recessivity cross-validated.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.
- Zinc, copper, and selenium levels in vitiligo: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Familial Versus Non-Familial Vitiligo: Clinical Features, Anatomical Distribution, and Autoimmune Comorbidity from a Southern Taiwan Hospital.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Vitiligo, from Pathogenesis to Therapeutic Advances: State of the Art.International journal of molecular sciences · 2023Review
- Management of Stable Vitiligo-A Review of the Surgical Approach.Journal of clinical medicine · 2023Review
- Current Concepts of Vitiligo Immunopathogenesis.Biomedicines · 2022Review
- Height and Risk of Vitiligo: A Nationwide Cohort Study.Journal of clinical medicine · 2021Article
- A Rare Case of Congenital Vitiligo in a Neonate.The Journal of clinical and aesthetic dermatology · 2021Article
- Translational Research in Vitiligo.Frontiers in immunology · 2021Review
- Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles.American journal of human genetics · 2019Article
- The convergence theory for vitiligo: A reappraisal.Experimental dermatology · 2019Review
- Effects of Extremely Low Frequency Electromagnetic Fields on Melanogenesis through p-ERK and p-SAPK/JNK Pathways in Human Melanocytes.International journal of molecular sciences · 2017Article
- Genetics of Vitiligo.Dermatologic clinics · 2017Review
- Vitiligo blood transcriptomics provides new insights into disease mechanisms and identifies potential novel therapeutic targets.BMC genomics · 2017Article
- Highlights in pathogenesis of vitiligo.World journal of clinical cases · 2015Review
- Melanocyte stem cells as potential therapeutics in skin disorders.Expert opinion on biological therapy · 2014Review
- Current aspects of vitiligo genetics.Postepy dermatologii i alergologii · 2014Review
- Involvement of interferon-gamma genetic variants and intercellular adhesion molecule-1 in onset and progression of generalized vitiligo.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2013Article
- Modern vitiligo genetics sheds new light on an ancient disease.The Journal of dermatology · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitiligo is a dermatological disorder characterized by hypopigmentary patches that tend to become progressive over time. There are reports of extensive familial aggregation. A genetic model for this disorder was earlier proposed by us. This model postulates that recessive alleles at multiple unlinked autosomal loci interact epistatically in the pathogenesis of vitiligo. The present family study was primarily undertaken to cross-validate the proposed genetic model. Data on 194 families from the United States were collected. Each family was ascertained through an affected proband. Analyses of these data reveal that approximately 20% of probands have at least one first-degree relative afflicted with vitiligo. All types of first-degree relatives of probands show a significant risk of developing vitiligo. Results of segregation and robustness analyses reveal that the genetic model postulated by us previously is the most parsimonious model for the present family data set.
Indexed as
Identifiers
7977362PMC1918341W1540646219What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.