ArticleAmerican journal of human genetics1994
The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN. III. Correlations and covariances.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005209 (Genetic Epidemiology of Coronary Heart Disease), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Coronary Heart Disease
Who cites it
15 citing papers in PubMed, 72 citations in OpenAlex.
- Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease.Current Alzheimer research · 2022Article
- Genetic Effects on the Correlation Structure of CVD Risk Factors: Exome-Wide Data From a Ghanaian Population.Global heart · 2017Review
- Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes.Journal of diabetes and metabolic disorders · 2012Article
- Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline.Neurobiology of aging · 2012Article
- Associations between apolipoprotein E genotype, diet, body mass index, and serum lipids in Lithuanian adult population.PloS one · 2012Article
- SHORT COMMUNICATION: Apolipoprotein E genotype and cognition in bipolar disorder.CNS neuroscience & therapeutics · 2010Article
- The relationship of the apolipoprotein E gene polymorphism Turkish Type 2 diabetic patients with and without nephropathy.Journal of endocrinological investigation · 2009Article
- Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey.Journal of assisted reproduction and genetics · 2009Article
- Patterns of cytokine profiles differ with pregnancy outcome and ethnicity.Human reproduction (Oxford, England) · 2008Article
- Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis.Genes and immunity · 2005Article
- Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism.Human genetics · 2004Article
- Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism.American journal of human genetics · 2002Article
- Angiotensin-converting enzyme and apolipoproteins genes polymorphism in coronary artery disease.Clinical cardiology · 2000Article
- Genotypes with the apolipoprotein epsilon4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men.Human genetics · 1996Article
- Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women.American journal of human genetics · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gender-specific influence that the apolipoprotein E (ApoE) polymorphism has on the correlations and covariances between pairs of nine plasma lipid and apolipoprotein traits (total cholesterol; in triglycerides; high-density-lipoprotein cholesterol; apolipoproteins AI, AII, B, CII, lnCIII, and lnE) was studied in 507 unrelated individuals representative of the adult population of Rochester, MN. Analyses are presented separately for females and males. The Apo E polymorphism had a significant influence on a large number (10 of 36) of correlations and covariances in females and on a small number (3 of 36) in males. The contribution of allelic variation in the Apo E gene to the definition of multivariate measures of the 36-dimensional correlation structure was evaluated. The influence of Apo E genotype on correlation structure was gender dependent. These findings were used to demonstrate how heterogeneity of risk-factor correlations and covariances among genotype-gender subgroups of the population at large may influence the evaluation of risk of coronary artery disease.
Indexed as
Identifiers
7977338PMC1918313W222711128What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.