ArticleProceedings of the National Academy of Sciences of the United States of America1994
Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 218 citations in OpenAlex.
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- The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation.British journal of pharmacology · 2017Article
- Niclosamide inhibits the inflammatory and angiogenic activation of human umbilical vein endothelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-κB modulation.Molecular cancer · 2014Article
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- Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor αSu/Fc fusion complex in syngeneic murine models of multiple myeloma.Cancer research · 2013Article
- Effects of a thrombomodulin-derived peptide on monocyte adhesion and intercellular adhesion molecule-1 expression in lipopolysaccharide-induced endothelial cells.Molecular vision · 2013Article
- MicroRNA-181b regulates NF-κB-mediated vascular inflammation.The Journal of clinical investigation · 2012Article
- Early growth response-1 contributes to steatosis development after acute ethanol administration.Alcoholism, clinical and experimental research · 2012Article
- The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.The Journal of biological chemistry · 2012Article
- Similar NF-κB gene signatures in TNF-α treated human endothelial cells and breast tumor biopsies.PloS one · 2011Article
- Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis.Cellular and molecular life sciences : CMLS · 2010Article
- IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- N-acetylcysteine in acute pancreatitis.World journal of gastrointestinal pharmacology and therapeutics · 2010Article
- Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Regulation of bacteria-induced intercellular adhesion molecule-1 by CCAAT/enhancer binding proteins.American journal of respiratory cell and molecular biology · 2009Article
- Heparin Attenuates the Expression of TNFalpha-induced Cerebral Endothelial Cell Adhesion Molecule.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene encoding intercellular adhesion molecule 1 (ICAM-1) is transcriptionally induced in response to inflammatory and immunomodulatory cytokines. To investigate the mechanisms controlling ICAM-1 gene expression, we have identified regulatory DNA sequences responsible for maintaining basal and mediating induced transcription in response to tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma). Regulatory elements centered 115, 60, and 40 bp upstream from the ICAM-1 transcription start site were implicated in cytokine-independent gene expression. Regulatory elements dedicated to TNF-alpha and IFN-gamma were identified 190 and 90 bp, respectively, upstream from the ICAM-1 transcription start site. A combination of mutagenesis and DNA-binding assays revealed that the TNF-alpha response element is composite, consisting of binding sites for both C/EBP and NF-kappa B. The IFN-gamma response element behaved as a simple regulatory element that selectively binds to an IFN-gamma-inducible activity composed, at least in part, of p91. These observations provide a framework for understanding how extracellular signals dynamically regulate the adhesive properties of mammalian cells.
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