ArticleProceedings of the National Academy of Sciences of the United States of America1994
Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed.
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- Pharmacological Network Analysis of the Functions and Mechanism of Quercetin From Jisuikang (JSK) in Spinal Cord Injury (SCI).Journal of cellular and molecular medicine · 2024Article
- Interactions between Cytokines and the Pathogenesis of Prion Diseases: Insights and Implications.Brain sciences · 2024Review
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
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- Neuroimmune system-mediated renal protection mechanisms.Clinical and experimental nephrology · 2021Review
- The call of the wild: using non-model systems to investigate microbiome-behaviour relationships.The Journal of experimental biology · 2021Review
- Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Pro- and anti-inflammatory properties of interleukin (IL6) in vitro: relevance for major depression and for human hippocampal neurogenesis.The international journal of neuropsychopharmacology · 2020Article
- Neuroimmune Communication in the Kidney.JMA journal · 2020Review
- Peripheral-to-central immune communication at the area postrema glial-barrier following bleomycin-induced sterile lung injury in adult rats.Brain, behavior, and immunity · 2020Article
- Role of neurons in the control of immune defense.Current opinion in immunology · 2019Review
- Progesterone receptor membrane component 1 inhibits tumor necrosis factor alpha induction of gene expression in neural cells.PloS one · 2019Article
- Exploiting the Multifaceted Effects of Cannabinoids on Mood to Boost Their Therapeutic Use Against Anxiety and Depression.Frontiers in molecular neuroscience · 2018Article
- Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis.Frontiers in immunology · 2017Article
- Ferulic acid prevents LPS-induced up-regulation of PDE4B and stimulates the cAMP/CREB signaling pathway in PC12 cells.Acta pharmacologica Sinica · 2016Article
- LPS and neuroinflammation: a matter of timing.Inflammopharmacology · 2016Review
- TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis.Journal of neuroinflammation · 2015Article
- Control of brain development, function, and behavior by the microbiome.Cell host & microbe · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Tumor necrosis factor alpha (TNF-alpha) is a cytokine that is responsible, in part, for several aspects of the acute-phase response to inflammation, including the generation of fever. TNF-alpha has direct effects on central nervous system neurons deep within the hypothalamus that are involved in producing the febrile response, but the blood-brain barrier prevents circulating TNF-alpha from having access to these sites. We therefore have hypothesized that TNF-alpha may be produced in the brain and used as a mediator in the cerebral components of the acute-phase response. We used in situ hybridization to determine the distribution of production of TNF-alpha mRNA in the mouse brain after systemic administration of lipopolysaccharide. During the initial phase of fever, hybridization was observed in perivascular cells and neurons in circumventricular organs, including the vascular organ of the lamina terminalis, median eminence, and area postrema, as well as along the ventral surface of the medulla; hybridization was also prominent over many cell in the meninges. During the late phase of the response, hybridization was observed over neurons in the pericircumventricular nuclei such as the anteroventral periventricular and arcuate nuclei of the hypothalamus and the nucleus of the solitary tract. TNF-alpha produced by a cascade of neurons within the brain may participate in the complex autonomic, neuroendocrine, metabolic, and behavioral responses to infection and inflammation.
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Registered trials
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