ArticleProceedings of the National Academy of Sciences of the United States of America1994
Construction, expression, and immunogenicity of the Schistosoma mansoni P28 glutathione S-transferase as a genetic fusion to tetanus toxin fragment C in a live Aro attenuated vaccine strain of Salmonella.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- Combining Well-Tempered Metadynamics Simulation and SPR Assays to Characterize the Binding Mechanism of the Universal T-Lymphocyte Tetanus Toxin Epitope TT830-843.BioMed research international · 2021Article
- The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils.Mucosal immunology · 2016Article
- Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope "tags".mAbs · 2015Article
- In vivo regulation of the Vi antigen in Salmonella and induction of immune responses with an in vivo-inducible promoter.Infection and immunity · 2011Article
- Oral immunization with attenuated Salmonella enterica serovar Typhimurium encoding Cryptosporidium parvum Cp23 and Cp40 antigens induces a specific immune response in mice.Clinical and vaccine immunology : CVI · 2009Article
- Tracking the dynamics of salmonella specific T cell responses.Current topics in microbiology and immunology · 2009Review
- Diminished amyloid-beta burden in Tg2576 mice following a prophylactic oral immunization with a salmonella-based amyloid-beta derivative vaccine.Journal of Alzheimer's disease : JAD · 2009Article
- An oral recombinant vaccine in dogs against Echinococcus granulosus, the causative agent of human hydatid disease: a pilot study.PLoS neglected tropical diseases · 2008Article
- Immunogenicity of cholera toxin B epitope inserted in Salmonella flagellin expressed on bacteria and administered as DNA vaccine.Molecular and cellular biochemistry · 2005Article
- Sm14 of Schistosoma mansoni in fusion with tetanus toxin fragment C induces immunoprotection against tetanus and schistosomiasis in mice.Infection and immunity · 2004Article
- Tetanus toxin fragment C expressed in live Salmonella vaccines enhances antibody responses to its fusion partner Schistosoma haematobium glutathione S-transferase.Infection and immunity · 2000Article
- Development of a nonantibiotic dominant marker for positively selecting expression plasmids in multivalent Salmonella vaccines.Applied and environmental microbiology · 2000Article
- Use of in vivo-regulated promoters to deliver antigens from attenuated Salmonella enterica var. Typhimurium.Infection and immunity · 1999Article
- Local and systemic neutralizing antibody responses induced by intranasal immunization with the nontoxic binding domain of toxin A from Clostridium difficile.Infection and immunity · 1999Article
- Expression and immunogenicity of a mutant diphtheria toxin molecule, CRM(197), and its fragments in Salmonella typhi vaccine strain CVD 908-htrA.Infection and immunity · 1999Article
- Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A.Infection and immunity · 1999Article
- Genetic control of immune response to recombinant antigens carried by an attenuated Salmonella typhimurium vaccine strain: Nramp1 influences T-helper subset responses and protection against leishmanial challenge.Infection and immunity · 1998Article
- Infection with Salmonella typhimurium modulates the immune response to Schistosoma mansoni glutathione-S-transferase.Infection and immunity · 1997Article
- Expression and immunogenicity of an Echinococcus granulosus fatty acid-binding protein in live attenuated Salmonella vaccine strains.Infection and immunity · 1997Article
- Vaccine efficacy of Salmonella strains expressing glycoprotein 63 with different promoters.Infection and immunity · 1997Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
A vector has been constructed to allow genetic fusions of guest antigens via a hinge domain to the C terminus of the highly immunogenic C fragment of tetanus toxin. A fusion has been constructed with the gene encoding the protective 28-kDa glutathione S-transferase (EC 2.5.1.18) from Schistosoma mansoni. The recombinant vector has been electroporated into the nonvirulent Salmonella typhimurium aroA live vaccine strain SL3261. The corresponding chimeric protein is stably expressed in a soluble form in Salmonella as evaluated by Western blotting with fragment C and glutathione S-transferase antisera. Mice immunized intravenously with a single dose of the live recombinant bacteria elicit antibodies to both fragment C and glutathione S-transferase as detected by enzyme-linked immunosorbent assays. Furthermore, all of the mice were solidly protected when challenged with lethal doses of either tetanus toxin or the virulent Salmonella typhimurium strain C5. Mice have also elicited antibodies to fragment C and glutathione S-transferase after oral immunization. It may be that a live trivalent vaccine against typhoid, tetanus, and schistosomiasis is feasible.
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