ArticleProceedings of the National Academy of Sciences of the United States of America1994
Major histocompatibility complex class I genes of the coelacanth Latimeria chalumnae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- Genome complexity in the coelacanth is reflected in its adaptive immune system.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Article
- The research of W.E. Mayer (1953-2012): a spectrum of immune systems.Immunogenetics · 2012Review
- Evolution and development of immunological structures in the lamprey.Current opinion in immunology · 2007Review
- A third broad lineage of major histocompatibility complex (MHC) class I in teleost fish; MHC class II linkage and processed genes.Immunogenetics · 2007Article
- Analysis of genomic and expressed major histocompatibility class Ia and class II genes in a hexaploid Lake Tana African 'large' barb individual (Barbus intermedius).Immunogenetics · 2004Article
- Characterization of a divergent non-classical MHC class I gene in sharks.Immunogenetics · 2003Article
- Late changes in spliceosomal introns define clades in vertebrate evolution.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Gene structure and amino acid sequence of Latimeria chalumnae (coelacanth) myelin DM20: phylogenetic relation of the fish.Neurochemical research · 1999Article
- The complete DNA sequence of the mitochondrial genome of a "living fossil," the coelacanth (Latimeria chalumnae).Genetics · 1997Article
- Characterization of class II A and B genes in a gynogenetic carp clone.Immunogenetics · 1996Article
- Identification and characterization of a new major histocompatibility complex class I gene in carp (Cyprinus carpio L.).Immunogenetics · 1996Article
- Identification of major histocompatibility complex genes in the guppy, Poecilia reticulata.Immunogenetics · 1996Article
- "Both man & bird & beast": comparative organization of MHC genes.Immunogenetics · 1995Review
- Cloning and characterization of class I Mhc genes of the zebrafish, Brachydanio rerio.Immunogenetics · 1995Article
- Sequence analysis of Mhc class II beta-like fragments in the pufferfish Fugu rubripes.Immunogenetics · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coelacanth fish Latimeria chalumnae is the sole surviving species of a phylogenetic lineage that was founded more than 400 million years ago and that has changed morphologically very little since that time. Little is known about the molecular evolution of this "living fossil," considered by some taxonomists to be the closest living relative of tetrapods. Here we describe the isolation and characterization of L. chalumnae major histocompatibility complex (MHC) class I genes. The exon-intron organization of these genes is the same as that of their mammalian counterparts. The genes fall into four families, which we designate Lach-UA through Lach-UD. There are multiple loci in all of the families. Genes of the first two families are transcribed. The Lach-UA family bears the characteristics of functional, polymorphic class I genes; the other three families may be represented by nonclassical genes. All the Lach loci arose by duplication from an ancestral gene after the foundation of the coelacanth lineage. Intergenic variation is highest at positions corresponding to the mammalian peptide-binding region. The closest relatives of the Lach genes among the MHC genes sequenced thus far are those of the amphibian Xenopus.
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