ArticleProceedings of the National Academy of Sciences of the United States of America1994
Rabies ribonucleocapsid as an oral immunogen and immunological enhancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- An ELISA-based method for detection of rabies virus nucleoprotein-specific antibodies in human antemortem samples.PloS one · 2018Article
- Article
- High level expression of a functionally active cholera toxin B: rabies glycoprotein fusion protein in tobacco seeds.Plant cell reports · 2009Article
- Nucleocapsid of rabies virus improve immune response of an inactivated avian influenza vaccine.Veterinary research communications · 2009Article
- Expression of the rabies virus nucleoprotein in plants at high-levels and evaluation of immune responses in mice.Plant cell reports · 2008Article
- Article
- Genetic characterization of rabies virus isolates in Korea.Virus genes · 2005Article
- Rabies virus nucleoprotein as a carrier for foreign antigens.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Rabies virus infects mouse and human lymphocytes and induces apoptosis.Journal of virology · 1997Article
- Antigens produced in plants by infection with chimeric plant viruses immunize against rabies virus and HIV-1.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Rabies superantigen as a Vbeta T-dependent adjuvant.The Journal of experimental medicine · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The administration of rabies ribonucleocapsid (RNP) by oral as well as parenteral routes was found to prime specific T cells and elicit N-protein-specific antibodies. per os and intramuscular immunization led to the production of antibodies of the IgA and IgG isotypes, respectively. Mice primed orally with RNP produced significantly enhanced amounts of virus-neutralizing antibody, compared with non-immune controls, upon subsequent parenteral booster immunization with inactivated rabies virus. Thus oral immunization with rabies RNP primed cells capable of mediating a secondary systemic response to rabies virus. The results of experiments in which peptide and protein antigens were administered either physically coupled to or mixed with RNP indicate that RNP has an inherent capacity to enhance immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.