ArticleNucleic acids research1994
SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Molecular Evolution and Diversification of Proteins Involved in miRNA Maturation Pathway.Plants (Basel, Switzerland) · 2020Article
- SUGP1 is a novel regulator of cholesterol metabolism.Human molecular genetics · 2016Article
- Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.Nucleic acids research · 2015Article
- Structure and assembly of the SF3a splicing factor complex of U2 snRNP.The EMBO journal · 2012Article
- The small ubiquitin-like modifier (SUMO) and SUMO-conjugating system of Chlamydomonas reinhardtii.Genetics · 2008Article
- The evolutionarily conserved TOUGH protein is required for proper development of Arabidopsis thaliana.The Plant cell · 2005Article
- Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability.BMC genomics · 2004Article
- Sorting out the complexity of SR protein functions.RNA (New York, N.Y.) · 2000Review
- The SRm160/300 splicing coactivator subunits.RNA (New York, N.Y.) · 2000Article
- Autoregulation of transformer-2 alternative splicing is necessary for normal male fertility in Drosophila.Genetics · 1998Article
- Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.Molecular and cellular biology · 1998Article
- The regulation of splice-site selection, and its role in human disease.American journal of human genetics · 1997Review
- Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae.Nucleic acids research · 1996Article
- SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element.Journal of virology · 1996Article
- Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor.Molecular and cellular biology · 1995Article
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4 authors.
Funding
Abstract
Regulators responsible for the pervasive, nonsex-specific alternative pre-mRNA splicing characteristic of metazoans are almost entirely unknown or uncertain. We describe here a novel family of splicing regulators present throughout metazoans. Specifically, we analyze two nematode (Caenorhabditis elegans) genes. One, CeSWAP, is a cognate of the suppressor-of-white-apricot (DmSWAP) splicing regulator from the arthropod Drosophila. Our results define the ancient, conserved SWAP protein family whose members share a colinearly arrayed series of novel sequence motifs. Further, we describe evidence that the CeSWAP protein autoregulates its levels by feedback control of splicing of its own pre-mRNA analogously to the DmSWAP protein and as expected of a splicing regulator. The second nematode gene, Ceprp21, encodes an abundant nuclear cognate of the constitutive yeast splicing protein, prp21, on the basis of several lines of evidence. Our analysis defines prp21 as a second novel, ancient protein family. One of the motifs conserved in prp21 proteins--designated surp--is shared with SWAP proteins. Several lines of evidence indicate that both new families of surp-containing proteins act at the same (or very similar) step in early prespliceosome assembly. We discuss implications of our results for regulated metazoan pre-mRNA splicing.
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