ArticlePflugers Archiv : European journal of physiology1994
Ultra-slow voltage-dependent inactivation of the calcium current in guinea-pig and ferret ventricular myocytes.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Calcium and arrhythmogenesis.Physiological reviews · 2007Pooled it
- Mechanisms underlying local CaThe Journal of physiology · 2025Article
- Models of the cardiac L-type calcium current: A quantitative review.WIREs mechanisms of disease · 2023Review
- Emergent synchronous beating behavior in spontaneous beating cardiomyocyte clusters.Scientific reports · 2021Article
- CaChannels (Austin, Tex.) · 2020Review
- Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study.The Journal of general physiology · 2020Article
- Two components of voltage-dependent inactivation in Ca(v)1.2 channels revealed by its gating currents.Biophysical journal · 2003Article
- Effects of glyburide (glibenclamide) on myocardial function in Langendorff perfused rabbit heart and on myocardial contractility and slow calcium current in guinea-pig single myocytes.Molecular and cellular biochemistry · 2003Article
- A model of the L-type Ca2+ channel in rat ventricular myocytes: ion selectivity and inactivation mechanisms.The Journal of physiology · 2000Article
- Modulation of slow inactivation in class A Ca2+ channels by beta-subunits.The Journal of physiology · 2000Article
- Differences in the effects of urinary incontinence agents S-oxybutynin and terodiline on cardiac K(+) currents and action potentials.British journal of pharmacology · 2000Article
- Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-)gallopamil.The Journal of physiology · 1999Article
- Block and modified gating of cardiac calcium channel currents by terodiline.British journal of pharmacology · 1999Article
- Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Ion-dependent inactivation of barium current through L-type calcium channels.The Journal of general physiology · 1997Article
- Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes.The Journal of physiology · 1996Article
- Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations.The Journal of general physiology · 1996Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
L-type Ca2+ current, iCa, has been recorded in guinea-pig ventricular myocytes at 36 degrees C using the whole cell patch clamp technique. Intracellular Ca2+ was buffered with ethylenebis(oxonitrilo)tetraacetate (EGTA). An increase in the rate of stimulation from 0.5 to 3 Hz resulted in an abrupt decrease in iCa in the first beat at the high rate, followed by a progressive decrease (tau approx. 7 s) over the next 30 s. The changes were not the result of Ca(2+)-dependent inactivation, because similar changes occurred with either Ba2+ or Na+ as the charge carrier. During 20-s voltage clamp pulses there was an ultra-slow phase of inactivation of Ba2+ or Na+ current through the Ca2+ channel (tau approx. 6 s at 0 mV). This was confirmed by applying test pulses after conditioning pulses of different duration: the Ba2+ current during the test pulse decreased progressively when the duration of the conditioning pulse was increased progressively to 20 s. Ultra-slow inactivation of Ba2+ current was voltage dependent and increased monotonically at more positive potentials. Recovery of Ba2+ current from ultra-slow inactivation occurred with a time constant of 3.7 s at -40 mV and 0.7 s at -80 mV. The gradual decrease in iCa on increasing the rate to 3 Hz may have been the result of the development of ultra-slow voltage-dependent inactivation.
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