ArticleMolecular and cellular biology1994
Identification and characterization of a novel GGA/C-binding protein, GBP-i, that is rapidly inducible by cytokines.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Microglia in antiviral immunity of the brain and spinal cord.Seminars in immunology · 2022Review
- Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.Clinical microbiology reviews · 2012Review
- Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene.Journal of virology · 2011Article
- Modulation of JC virus transcription by C/EBPbeta.Virus research · 2009Article
- Regulation of gene expression in primate polyomaviruses.Journal of virology · 2009Review
- Early growth response-1 protein is induced by JC virus infection and binds and regulates the JC virus promoter.Virology · 2008Article
- Interferon beta1-a and selective anti-5HT(2a) receptor antagonists inhibit infection of human glial cells by JC virus.Virus research · 2008Article
- Members of the AP-1 family, c-Jun and c-Fos, functionally interact with JC virus early regulatory protein large T antigen.Journal of virology · 2003Article
- Advances in the biology of JC virus and induction of progressive multifocal leukoencephalopathy.Journal of neurovirology · 2003Article
- An overview: Human polyomavirus JC virus and its associated disorders.Journal of neurovirology · 2003Review
- Functional interaction between JC virus late regulatory agnoprotein and cellular Y-box binding transcription factor, YB-1.Journal of virology · 2002Article
- Epidemiological evidence and molecular basis of interactions between HIV and JC virus.Journal of neurovirology · 2001Review
- Physical and functional interaction between viral and cellular proteins modulate JCV gene transcription.Journal of neurovirology · 2001Review
- Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial cells.Journal of virology · 2001Article
- Regulation of Epstein-Barr virus promoters in oral epithelial cells and lymphocytes.Journal of virology · 1999Article
- [Progressive multifocal leukoencephalopathy].Medizinische Klinik (Munich, Germany : 1983) · 1999Review
- Cytokine-mediated reversal of multidrug resistance.Cytotechnology · 1998Article
- Transcriptional regulation of human polyomavirus JC: evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1.Journal of virology · 1996Article
- Transcription of the JC virus archetype late genome: importance of the kappa B and the 23-base-pair motifs in late promoter activity in glial cells.Journal of virology · 1996Article
- Transcriptional regulation of human JC polyomavirus promoters by cellular proteins YB-1 and Pur alpha in glial cells.Journal of virology · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunosuppressive states with accompanying alterations in cytokine profiles have been postulated to play a vital role in the reactivation of viruses from latency. Cytokines regulate gene expression by activating transcription factors via well-characterized signal transduction pathways. In this study, we report the identification of a novel inducible protein, GBP-i, that binds to a double-stranded GGA/C-rich region of the transcriptional control region of the human papovavirus JC virus (JCV), specifically within the origin of viral DNA replication. GBP-i is distinct from previously characterized GC-box-binding proteins with respect to both its sequence specificity and its electrophoretic mobility on native and denaturing gels. GBP-i responds within 90 min to phorbol myristate acetate stimulation; however, unlike typical phorbol myristate acetate-inducible factors, this rapid induction is regulated primarily at the transcriptional level. Further, the induction of GBP-i appears to be widespread and mediated by many inflammatory cytokines, including interleukin-1 beta, tumor necrosis factor alpha, gamma interferon, and transforming growth factor beta. Interestingly, the induced protein acts as a transcriptional repressor in its native context in the JCVL promoter. However, when its binding sequence is transposed to a heterologous promoter, GBP-i appears to function as a transcriptional activator. The data presented here suggest a role for GBP-i in cytokine-mediated induction of viral and cellular genes.
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