ArticleMolecular and cellular biology1994
Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer's disease.BMC genomics · 2024Article
- Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.Cellular and molecular life sciences : CMLS · 2018Review
- The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer's Disease?Molecular neurobiology · 2016Review
- Comparative FAIRE-seq analysis reveals distinguishing features of the chromatin structure of ground state- and primed-pluripotent cells.Stem cells (Dayton, Ohio) · 2015Article
- Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells.PloS one · 2013Article
- Transcription factor heterogeneity and epiblast pluripotency.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
- Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells.Journal of cell science · 2011Article
- Embryonic stem cells: protein interaction networks.Biomolecular concepts · 2011Article
- Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.The Journal of biological chemistry · 2009Article
- Regulation of the Nanog gene by both positive and negative cis-regulatory elements in embryonal carcinoma cells and embryonic stem cells.Molecular reproduction and development · 2009Article
- Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes.Nucleic acids research · 2007Article
- SOX2 is a dose-dependent regulator of retinal neural progenitor competence.Genes & development · 2006Article
- Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.Molecular and cellular biology · 2005Article
- Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.Molecular and cellular biology · 2005Article
- The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.The Biochemical journal · 2003Article
- Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers.Genes & development · 2003Article
- Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development.Molecular and cellular biology · 2003Article
- FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice.Genes & development · 2002Article
- SSRP1 functions as a co-activator of the transcriptional activator p63.The EMBO journal · 2002Article
- Oct4 distribution and level in mouse clones: consequences for pluripotency.Genes & development · 2002Article
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Authors and funding
3 authors.
Funding
Abstract
Understanding how diverse transcription patterns are achieved through common factor binding elements is a fundamental question that underlies much of developmental and cellular biology. One example is provided by the fibroblast growth factor 4 (FGF-4) gene, whose expression is restricted to specific embryonic tissues during development and to undifferentiated embryonal carcinoma cells in tissue culture. Analysis of the cis- and trans-acting elements required for the activity of the previously identified FGF-4 enhancer in F9 embryonal carcinoma cells showed that enhancer function depends on sequences that bind Sp1 and ubiquitous as well as F9-specific octamer-binding proteins. However, sequences immediately upstream of the octamer motif, which conform to a binding site for the high-mobility group (HMG) domain factor family, were also critical to enhancer function. We have identified a novel F9-specific factor, Fx, which specifically recognizes this motif. Fx formed complexes with either Oct-1 or Oct-3 in a template-dependent manner. The ability of different enhancer variants to form the Oct-Fx complexes correlated with enhancer activity, indicating that these complexes play an essential role in transcriptional activation of the FGF-4 gene. Thus, while FGF-4 enhancer function is octamer site dependent, its developmentally restricted activity is determined by the interaction of octamer-binding proteins with the tissue-specific factor Fx.
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