ArticleMolecular & general genetics : MGG1994
Carbon catabolite repression in Kluyveromyces lactis: isolation and characterization of the KIDLD gene encoding the mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase.
Article in Molecular & general genetics : MGG, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.Nature communications · 2023Article
- A D-lactate dehydrogenase from rice is involved in conferring tolerance to multiple abiotic stresses by maintaining cellular homeostasis.Scientific reports · 2020Article
- The ancestors of diatoms evolved a unique mitochondrial dehydrogenase to oxidize photorespiratory glycolate.Photosynthesis research · 2017Article
- Silencing of D-Lactate Dehydrogenase Impedes Glyoxalase System and Leads to Methylglyoxal Accumulation and Growth Inhibition in Rice.Frontiers in plant science · 2017Article
- d-Lactate Dehydrogenase Links Methylglyoxal Degradation and Electron Transport through Cytochrome c.Plant physiology · 2016Article
- Laboratory Prototype of Bioreactor for Oxidation of Toxic D-Lactate Using Yeast Cells Overproducing D-Lactate Cytochrome c Oxidoreductase.BioMed research international · 2016Article
- Identification of the Elusive Pyruvate Reductase of Chlamydomonas reinhardtii Chloroplasts.Plant & cell physiology · 2016Article
- Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.The Journal of biological chemistry · 2009Article
- D- and L-lactate dehydrogenases during invertebrate evolution.BMC evolutionary biology · 2008Article
- The deletion of the succinate dehydrogenase gene KlSDH1 in Kluyveromyces lactis does not lead to respiratory deficiency.Eukaryotic cell · 2004Article
- Improved production of heterologous proteins by a glucose repression-defective mutant of Kluyveromyces lactis.Applied and environmental microbiology · 2004Article
- Three target genes for the transcriptional activator Cat8p of Kluyveromyces lactis: acetyl coenzyme A synthetase genes KlACS1 and KlACS2 and lactate permease gene KlJEN1.Journal of bacteriology · 2001Article
- RAG4 gene encodes a glucose sensor in Kluyveromyces lactis.Genetics · 2001Article
- The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn(2+) flavoprotein.Journal of bacteriology · 1999Article
- glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein.Journal of bacteriology · 1996Article
- FOG1 and FOG2 genes, required for the transcriptional activation of glucose-repressible genes of Kluyveromyces lactis, are homologous to GAL83 and SNF1 of saccharomyces cerevisiae.Current genetics · 1996Article
- Carbon catabolite regulation of transcription of nuclear genes coding for mitochondrial proteins in the yeast Kluyveromyces lactis.Current genetics · 1995Article
- Genes coding for mitochondrial proteins are more strongly biased in Kluyveromyces lactis than in Saccharomyces cerevisiae.Current genetics · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the "petite-negative" yeast Kluyveromyces lactis carbon catabolite repression of some cytoplasmic enzymes has been observed. However, with respect to mitochondrial enzymes, in K. lactis, unlike the case in the "petite-positive" yeast Saccharomyces cerevisiae, growth on fermentable carbon sources does not cause repression of respiratory enzymes. In this paper data are reported on carbon catabolite repression of mitochondrial enzymes in K. lactis, in particular on L- and D-lactate ferricytochrome c oxidoreductase (LCR). The L- and D-LCR (E.C. 1123, E.C. 1124) in yeast catalyze the stereospecific oxidation of D and L isomers of lactate to pyruvate. This pathway is linked to the respiratory chain, cytochrome c being the electron acceptor of the redox reaction. We demonstrate that the level of mitochondrial D- and L-LCR is controlled by the carbon source, being induced by the substrate lactate and catabolite-repressed by glucose. We cloned the structural gene for D-LCR of K. lactis (KlDLD), by complementation of growth on D,L-lactate in the S. cerevisiae strain WWF18-3D, carrying both a CYB2 disruption and the dld mutation. From the sequence analysis an open reading frame was identified that could encode a polypeptide of 579 amino acids, corresponding to a calculated molecular weight of 63,484 Da. Analysis of mRNA expression indicated that glucose repression and induction by lactate are exerted at the transcriptional level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.