ReviewMicrobiological reviews1994
Developmental decisions in Dictyostelium discoideum.
Review in Microbiological reviews, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 114 citations in OpenAlex.
- Article
- Multi-omics analysis of aggregative multicellularity.iScience · 2024Article
- Transfer entropy dependent on distance among agents in quantifying leader-follower relationships.Biophysics and physicobiology · 2021Article
- Scenario-targeted toxicity assessment through multiple endpoint bioassays in a soil posing unacceptable environmental risk according to regulatory screening values.Environmental science and pollution research international · 2015Article
- Role of the Skp1 prolyl-hydroxylation/glycosylation pathway in oxygen dependent submerged development of Dictyostelium.BMC developmental biology · 2012Article
- Phospholipase D controls Dictyostelium development by regulating G protein signaling.Cellular signalling · 2011Article
- Acidic Ca2+ stores, excitability, and cell patterning in Dictyostelium discoideum.Eukaryotic cell · 2009Review
- Regulation of ammonia homeostasis by the ammonium transporter AmtA in Dictyostelium discoideum.Eukaryotic cell · 2007Article
- A cysteine-rich extracellular protein containing a PA14 domain mediates quorum sensing in Dictyostelium discoideum.Eukaryotic cell · 2005Article
- PldB, a putative phospholipase D homologue in Dictyostelium discoideum mediates quorum sensing during development.Eukaryotic cell · 2005Article
- Multicellular microorganisms: laboratory versus nature.EMBO reports · 2004Review
- Intercellular signaling in Stigmatella aurantiaca: purification and characterization of stigmolone, a myxobacterial pheromone.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserina.The EMBO journal · 1998Article
- A way of following individual cells in the migrating slugs of Dictyostelium discoideum.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Origin and evolution of the slime molds (Mycetozoa)Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- C factor, a cell-surface-associated intercellular signaling protein, stimulates the cytoplasmic Frz signal transduction system in Myxococcus xanthus.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Calmidazolium leads to an increase in the cytosolic Ca2+ concentration in Dictyostelium discoideum by induction of Ca2+ release from intracellular stores and influx of extracellular Ca2+.The Biochemical journal · 1996Article
- Cell adhesion in the life cycle of Dictyostelium.Experientia · 1995Review
- Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A few hours after the onset of starvation, amoebae of Dictyostelium discoideum start to form multicellular aggregates by chemotaxis to centers that emit periodic cyclic AMP signals. There are two major developmental decisions: first, the aggregates either construct fruiting bodies directly, in a process known as culmination, or they migrate for a period as "slugs." Second, the amoebae differentiate into either prestalk or prespore cells. These are at first randomly distributed within aggregates and then sort out from each other to form polarized structures with the prestalk cells at the apex, before eventually maturing into the stalk cells and spores of fruiting bodies. Developmental gene expression seems to be driven primarily by cyclic AMP signaling between cells, and this review summarizes what is known of the cyclic AMP-based signaling mechanism and of the signal transduction pathways leading from cell surface cyclic AMP receptors to gene expression. Current understanding of the factors controlling the two major developmental choices is emphasized. The weak base ammonia appears to play a key role in preventing culmination by inhibiting activation of cyclic AMP-dependent protein kinase, whereas the prestalk cell-inducing factor DIF-1 is central to the choice of cell differentiation pathway. The mode of action of DIF-1 and of ammonia in the developmental choices is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.