ReviewJournal of inherited metabolic disease1994
Genetic imprinting in the mouse: implications for gene regulation.
Review in Journal of inherited metabolic disease, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 57 citations in OpenAlex.
- A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Genomic imprinting: implications for human disease.The American journal of pathology · 1999Review
- Regulation of X-chromosome inactivation in development in mice and humans.Microbiology and molecular biology reviews : MMBR · 1998Review
- Competition--a common motif for the imprinting mechanism?The EMBO journal · 1997Review
- The mouse chromosome 7 distal imprinting domain maps to G-bands F4/F5.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- The structural H19 gene is required for transgene imprinting.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The role of the laboratory mouse in the human genome project.American journal of human genetics · 1996Review
- Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein lipase deficiency.American journal of human genetics · 1996Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic imprinting specifies a germline marking that subsequently results in the repression of one or other parental allele at some point in development. Genetic manipulations to generate maternal and paternal duplications of specific chromosome regions have been used to screen almost the entire mouse genome for evidence of imprinting. As a result, 15 imprinting effects involving 10 regions on 6 different chromosomes have been detected that range from early embryonic lethalities to various growth and developmental defects seen only after birth. Genes with important roles in development therefore appear to be involved. Diverse studies have identified four imprinted genes, all of which show monoallelic expression in some, but not necessarily all, tissues. A correlation with methylation is indicated but the pattern of methylation is not consistent for each of the genes; methylation is therefore unlikely to be the imprinting signal. Methods being used to identify further imprinted genes are summarized and some of the difficulties posed are indicated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.