Trial reportThe Journal of physiology1994
A study of the action of bradykinin and bradykinin analogues in the human nasal airway.
Trial report in The Journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- Subjects with non-allergic non-infectious perennial rhinitis do not show nasal hyper-responsiveness to bradykinin.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2007Trial
- Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway.British journal of pharmacology · 2000Trial
- Specific immunotherapy with mugwort pollen allergoid reduce bradykinin release into the nasal fluid.Postepy dermatologii i alergologii · 2016Article
- Article
- Immunohistochemical localization of the bradykinin B1 and B2 receptors in human nasal mucosa.Mediators of inflammation · 2009Article
- Characterization of the bradykinin receptor in the human nasal airway using the binding of [125I]-Hoe 140.British journal of pharmacology · 1996Article
- Attenuation of human nasal airway responses to bradykinin and histamine by inhibitors of nitric oxide synthase.British journal of pharmacology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The aim of this study was to investigate the action of bradykinin on resistance to airflow and on vascular permeability in the human nasal airway, and to explore the receptor mediating these effects. 2. Aerosol administration of bradykinin (10-1000 micrograms) caused a dose-related increase in nasal airway resistance (NAR) and an increase in albumin content of nasal lavage. 3. The bradykinin antagonists, [1-adamantane acetyl-D-Arg0, Hyp3, Thi5,8, D-Phe7]-bradykinin, 100 micrograms, and [D-Arg0, Hyp3, Thi5, D-Tic7, Oic8]-bradykinin, 100 micrograms, given 2 min before bradykinin, inhibited the increase in NAR and the increase of albumin content of nasal lavage caused by bradykinin. 4. The bradykinin antagonist, [D-Arg0, Hyp3, D-Phe7]-bradykinin (100 micrograms) did not affect the increase in NAR produced by bradykinin, or the albumin content of nasal lavage. Increasing the dose of the antagonist to 1000 micrograms did not change the increase in NAR induced by bradykinin. 5. The selective B1 kinin receptor agonist, [Des-Arg10]-kallidin (100 micrograms) did not affect NAR or the albumin content of nasal lavage. 6. The receptor mediating increased NAR and the release of albumin induced by bradykinin in the human nasal airway appears not to be a B1 kinin receptor. The data are not entirely consistent with the effects of bradykinin in the human nasal airway being mediated by a B2 kinin receptor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.