ArticleThe Journal of experimental medicine1994
T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- QTL analyses of lineage-negative mouse bone marrow cells labeled with Sca-1 and c-Kit.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Pre-B lymphomas in SL/Kh mice: a multifactorial disease model.Cancer science · 2003Review
- Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas.Cancer science · 2003Article
- Article
- Failure of ureteric bud invasion: a new model of renal agenesis in mice.The American journal of pathology · 2001Article
- Mixed phenotype lymphomas in thymectomized (SL/KhxAKR/Ms)F1 mice.Japanese journal of cancer research : Gann · 1999Article
- Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis.British journal of cancer · 1999Article
- Quantitative trait loci associated with promoting effects of sodium L-ascorbate on two-stage bladder carcinogenesis in rats.Japanese journal of cancer research : Gann · 1997Article
- Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats.Japanese journal of cancer research : Gann · 1996Article
- Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas.Japanese journal of cancer research : Gann · 1996Article
- Genetic and epigenetic resistance of SL/Ni mice to lymphomas.Japanese journal of cancer research : Gann · 1996Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility to T lymphomas in mice is determined by a number of viral and host genetic factors. We analyzed the types and latent period of lymphomas spontaneously occurring in crosses between AKR/Ms, a T lymphoma-prone mouse strain, and SL/Kh, a pre-B lymphoma-prone strain. The incidence of T lymphomas in the F1 hybrids backcross to SL/Kh as well as F2 generation mice indicated that a dominant host gene thymic lymphoma susceptible mouse-1 (Tlsm-1) of AKR/Ms determined the type of lymphomas to be thymic. Linkage analysis with microsatellite markers assigned Tlsm-1 to the map position 61 cM from centromere of the chromosome 7. Close scrutiny of this region of AKXD recombinant inbred strains for spontaneous T lymphomas revealed the presence of Tlsm-1-like gene most likely between D7MIT71 (map position 62) and D7MIT13 (map position 70). On the other hand, a SL/Kh-derived recessive allele at a major histocompatibility complex (MHC)-linked locus accelerated development of both T and B lymphomas.
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