ArticleThe Journal of clinical investigation1994
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 209 citations in OpenAlex.
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- Circular RNAs: emerging players in asthma and COPD.Frontiers in cell and developmental biology · 2023Review
- Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis.Cellular and molecular life sciences : CMLS · 2021Review
- Bcl2-induced DNA replication stress promotes lung carcinogenesis in response to space radiation.Carcinogenesis · 2020Article
- Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates.International archives of occupational and environmental health · 2017Article
- T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways.Respiratory research · 2016Article
- Efficacious and safe orotracheal intubation for laboratory mice using slim torqueable guidewire-based technique: comparisons between a modified and a conventional method.BMC anesthesiology · 2016Article
- Critical role of IL-6 in dendritic cell-induced allergic inflammation of asthma.Journal of molecular medicine (Berlin, Germany) · 2016Article
- IL-6 Plays a Crucial Role in HBV Infection.Journal of clinical and translational hepatology · 2015Review
- IL-6 as a keystone cytokine in health and disease.Nature immunology · 2015Review
- Animal Models, Learning Lessons to Prevent and Treat Neonatal Chronic Lung Disease.Frontiers in medicine · 2015Review
- Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.The Journal of clinical investigation · 2014Article
- Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium.The Journal of general virology · 2014Article
- Experimental induction of lung damage in the f344 rat upon exposure to citral, retinoic Acid (atra), ovalbumin and mold spores.Biomedical sciences instrumentation · 2014Article
- One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure.Respiratory medicine · 2014Article
- The enigmatic cytokine oncostatin m and roles in disease.ISRN inflammation · 2013Review
- A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung.PloS one · 2013Article
- Airway smooth muscle in asthma: just a target for bronchodilation?Clinics in chest medicine · 2012Review
- Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation.American journal of respiratory cell and molecular biology · 2012Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We produced transgenic mice which overexpress human IL-6 in the airway epithelial cells. Transgenic mice develop a mononuclear cell infiltrate adjacent to large and mid-sized airways. Immunohistochemistry reveals these cells to be predominantly CD4+ cells, MHC class II+ cells, and B220+ cells. Transgenic mice and nontransgenic mice had similar baseline respiratory system resistance (0.47 +/- 0.06 vs 0.43 +/- 0.04 cmH2O/ml per s at 9 wk of age, P = NS and 0.45 +/- 0.07 vs 0.43 +/- 0.09 cmH2O/ml per s at 17 wk of age, P = NS). Transgenic mice, however, required a significantly higher log dose of methacholine to produce a 100% increase in respiratory system resistance as compared with non-transgenic littermates (1.34 +/- 0.24 vs 0.34 +/- 0.05 mg/ml, P < or = 0.01). We conclude that the expression of human IL-6 in the airways of transgenic mice results in a CD4+, MHC class II+, B220+ lymphocytic infiltrate surrounding large and mid-sized airways that does not alter basal respiratory resistance, but does diminish airway reactivity to methacholine. These findings demonstrate an uncoupling of IL-6-induced airway lymphocytic inflammation and airway hyperresponsiveness and suggest that some forms of airway inflammation may serve to restore altered airway physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.