ArticleThe Journal of cell biology1994
Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 141 citations in OpenAlex.
- Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease.International journal of molecular sciences · 2023Review
- Development of the Placenta and Brain Are Affected by Selective Serotonin Reuptake Inhibitor Exposure During Critical Periods.Advances in experimental medicine and biology · 2023Review
- SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3.The Journal of cell biology · 2022Article
- Visualization of Partial Exocytotic Content Release and Chemical Transport into Nanovesicles in Cells.ACS nano · 2022Article
- Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response.PLoS genetics · 2022Article
- Simultaneous detection of vesicular content and exocytotic release with two electrodes in and at a single cell.Chemical science · 2021Article
- The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Differential sorting behavior for soluble and transmembrane cargoes at theMolecular biology of the cell · 2020Article
- Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits.BMC evolutionary biology · 2019Article
- Inhibitory role of peroxiredoxin 2 in LRRK2 kinase activity induced cellular pathogenesis.Journal of biomedical research · 2019Article
- Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- HID-1 controls formation of large dense core vesicles by influencing cargo sorting andMolecular biology of the cell · 2017Article
- Alpha-synuclein modulates dopamine neurotransmission.Journal of chemical neuroanatomy · 2017Review
- Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant hepatocarcinoma cells.Frontiers of medicine · 2017Article
- Retrograde trafficking of VMAT2 and its role in protein stability in non-neuronal cells.Journal of biomedical research · 2016Article
- The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Complexity of dopamine metabolism.Cell communication and signaling : CCS · 2013Article
- Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.PLoS genetics · 2013Article
- RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway.The Journal of cell biology · 2010Article
- A tyrosine-based motif localizes a Drosophila vesicular transporter to synaptic vesicles in vivo.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons and endocrine cells have two types of secretory vesicle that undergo regulated exocytosis. Large dense core vesicles (LDCVs) store neural peptides whereas small clear synaptic vesicles store classical neurotransmitters such as acetylcholine, gamma-aminobutyric acid (GABA), glycine, and glutamate. However, monoamines differ from other classical transmitters and have been reported to appear in both LDCVs and smaller vesicles. To localize the transporter that packages monoamines into secretory vesicles, we have raised antibodies to a COOH-terminal sequence from the vesicular amine transporter expressed in the adrenal gland (VMAT1). Like synaptic vesicle proteins, the transporter occurs in endosomes of transfected CHO cells, accounting for the observed vesicular transport activity. In rat pheochromocytoma PC12 cells, the transporter occurs principally in LDCVs by both immunofluorescence and density gradient centrifugation. Synaptic-like microvesicles in PC12 cells contain relatively little VMAT1. The results appear to account for the storage of monoamines by LDCVs in the adrenal medulla and indicate that VMAT1 provides a novel membrane protein marker unique to LDCVs.
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Registered trials
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