ArticleThe Journal of cell biology1994
The Drosophila lethal(2)giant larvae tumor suppressor protein is a component of the cytoskeleton.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 130 citations in OpenAlex.
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- Lateral cell polarization drives organization of epithelia in sea anemone embryos and embryonic cell aggregates.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Lateral cell polarization drives organization of epithelia in sea anemone embryos and embryonic cell aggregates.bioRxiv : the preprint server for biology · 2024Article
- Apocrine secretion in the salivary glands ofFrontiers in cell and developmental biology · 2022Article
- How cells tell up from down and stick together to construct multicellular tissues - interplay between apicobasal polarity and cell-cell adhesion.Journal of cell science · 2021Review
- An apocrine mechanism delivers a fully immunocompetent exocrine secretion.Scientific reports · 2021Article
- Scribble, Lgl1, and myosin II form a complex in vivo to promote directed cell migration.Molecular biology of the cell · 2020Article
- The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in theAmerican journal of physiology. Cell physiology · 2020Article
- Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis.Nature communications · 2016Article
- Occluding junctions of invertebrate epithelia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons.Bioarchitecture · 2016Article
- Hugl-1 inhibits glioma cell growth in intracranial model.Journal of neuro-oncology · 2015Article
- Changes in organelle position and epithelial architecture associated with loss of CrebA.Biology open · 2015Article
- Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation.Development (Cambridge, England) · 2014Article
- The lethal giant larvae gene in Tribolium castaneum: molecular properties and roles in larval and pupal development as revealed by RNA interference.International journal of molecular sciences · 2014Article
- Function and cancer genomics of FAT family genes (review).International journal of oncology · 2012Review
- The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration.Molecular biology of the cell · 2012Article
- Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.Advances in experimental medicine and biology · 2012Article
- Asymmetric cell division: recent developments and their implications for tumour biology.Nature reviews. Molecular cell biology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor suppressor genes act as recessive determinants of cancer. In Drosophila these genes play a role in normal development and are essential for regulating cell growth and differentiation. Mutations in the gene, lethal(2)giant larvae, l(2)gl, besides causing malignant tumors in the brain and imaginal discs, generate developmental defects in a number of other tissues. Much of the uncertainty regarding the function of the l(2)gl gene product, p127, results from a lack of knowledge as to the precise location of this protein in the cell. We have investigated the cellular and subcellular localization of p127, using confocal and electron microscopy as well as biochemical and cell fractionation procedures. Our analyses indicate that p127 is located entirely within the cell in both the cytoplasm and bound to the inner face of lateral cell membranes in regions of cell junctions. On the membrane, p127 can form large aggregates which are resistant to solubilization by nonionic detergents, indicating that p127 is participating in a cytoskeletal matrix. These findings suggest that the changes in cell shape and the loss of apical-basal polarity observed in tumorous tissues are a direct result of alterations in the cytoskeleton organization caused by l(2)gl inactivation and also suggest that p127 is involved in a cytoskeletal-based intercellular communication system directing cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.