ArticleThe Journal of cell biology1994
Members of the fatty acid binding protein family are differentiation factors for the mammary gland.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 114 citations in OpenAlex.
- Translational potential of GADD45α: biomarker and therapeutic target in age-associated neurodegeneration and longevity.Biogerontology · 2025Review
- Identification of a novel signature with prognostic value in triple-negative breast cancer through clinico-transcriptomic analysis.Annals of translational medicine · 2022Article
- To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence.Stem cells international · 2021Review
- Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR-α signaling.Journal of lipid research · 2019Article
- Challenges in enriching milk fat with polyunsaturated fatty acids.Journal of animal science and biotechnology · 2015Article
- iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors.PloS one · 2015Article
- Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile.Developmental biology · 2010Article
- In utero exposure to bisphenol A shifts the window of susceptibility for mammary carcinogenesis in the rat.Environmental health perspectives · 2010Article
- Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5.PloS one · 2010Article
- Structural and functional analysis of fatty acid-binding proteins.Journal of lipid research · 2009Review
- Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation.The American journal of pathology · 2009Article
- The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure.BMC genomics · 2007Article
- Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome.Current atherosclerosis reports · 2007Review
- The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism.Journal of applied genetics · 2006Review
- Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin.Oncogene · 2003Article
- Localization of brain-type fatty acid-binding protein in Kupffer cells of mice and its transient decrease in response to lipopolysaccharide.Histochemistry and cell biology · 2003Article
- Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP).The Biochemical journal · 2002Article
- Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells.Molecular and cellular biochemistry · 2001Article
- Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland.Transgenic research · 2000Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammary gland development is controlled by systemic hormones and by growth factors that might complement or mediate hormonal action. Peptides that locally signal growth cessation and stimulate differentiation of the developing epithelium have not been described. Here, we report that recombinant and wild-type forms of mammary-derived growth inhibitor (MDGI) and heart-fatty acid binding protein (FABP), which belong to the FABP family, specifically inhibit growth of normal mouse mammary epithelial cells (MEC), while growth of stromal cells is not suppressed. In mammary gland organ culture, inhibition of ductal growth is associated with the appearance of bulbous alveolar end buds and formation of fully developed lobuloalveolar structures. In parallel, MDGI stimulates its own expression and promotes milk protein synthesis. Selective inhibition of endogenous MDGI expression in MEC by antisense phosphorothioate oligonucleotides suppresses appearance of alveolar end buds and lowers the beta-casein level in organ cultures. Furthermore, MDGI suppresses the mitogenic effects of epidermal growth factor, and epidermal growth factor antagonizes the activities of MDGI. Finally, the regulatory properties of MDGI can be fully mimicked by an 11-amino acid sequence, represented in the COOH terminus of MDGI and a subfamily of structurally related FABPs. This peptide does not bind fatty acids. To our knowledge, this is the first report about a growth inhibitor promoting mammary gland differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.