ArticleThe Journal of cell biology1994
Neural regulation of acetylcholinesterase mRNAs at mammalian neuromuscular synapses.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 86 citations in OpenAlex.
- HuR Mediates Changes in the Stability of AChR β-Subunit mRNAs after Skeletal Muscle Denervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Limiting role of protein disulfide isomerase in the expression of collagen-tailed acetylcholinesterase forms in muscle.The Journal of biological chemistry · 2009Article
- Assembly and regulation of acetylcholinesterase at the vertebrate neuromuscular junction.Chemico-biological interactions · 2008Article
- Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling.Nucleic acids research · 2008Article
- Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice.Molecular biology of the cell · 2007Article
- The role of muscle activation pattern and calcineurin in acetylcholinesterase regulation in rat skeletal muscles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Expression of the P2Y1 nucleotide receptor in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Local control of acetylcholinesterase gene expression in multinucleated skeletal muscle fibers: individual nuclei respond to signals from the overlying plasma membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Stability and secretion of acetylcholinesterase forms in skeletal muscle cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- An intronic enhancer containing an N-box motif is required for synapse- and tissue-specific expression of the acetylcholinesterase gene in skeletal muscle fibers.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Acetylcholinesterase mRNA level and synaptic activity in rat muscles depend on nerve-induced pattern of muscle activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Review
- Transplantation of quail collagen-tailed acetylcholinesterase molecules onto the frog neuromuscular synapse.The Journal of cell biology · 1997Article
- Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle.The Journal of cell biology · 1995Article
- Nerve-dependent regulation of succinate dehydrogenase in junctional and extrajunctional compartments of rat muscle fibres.The Journal of physiology · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the role of innervation on acetylcholinesterase (AChE) gene expression within mammalian skeletal muscle fibers. First, we showed the selective accumulation of AChE mRNAs within the junctional vs extrajunctional sarcoplasm of adult muscle fibers using a quantitative reverse transcription PCR assay and demonstrated by in situ hybridization experiments that AChE transcripts are concentrated immediately beneath the postsynaptic membrane of the neuromuscular junction. Next, we determined the influence of nerve-evoked activity vs putative trophic factors on the synaptic accumulation of AChE mRNA levels in muscle fibers paralyzed by either surgical denervation or selective blockage of nerve action potentials with chronic superfusion of tetrodotoxin. Our results indicated that muscle paralysis leads to a marked decrease in AChE transcripts from the postsynaptic sarcoplasm, yet the extent of this decrease is less pronounced after tetrodotoxin inactivation than after denervation. These results suggest that although nerve-evoked activity per se appears a key regulator of AChE mRNA levels, the integrity of the synaptic structure or the release of putative trophic factors contribute to maintaining the synaptic accumulation of AChE transcripts at adult neuromuscular synapses. Furthermore, the pronounced downregulation of AChE transcripts in paralyzed muscles stands in sharp contrast to the well-documented increase in nicotinic acetylcholine receptor mRNAs under these conditions, and indicates that expression of the genes encoding these two synaptic proteins are subjected to different regulatory mechanisms in adult muscle fibers in vivo.
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