ArticleThe Journal of cell biology1994
Golgi spectrin: identification of an erythroid beta-spectrin homolog associated with the Golgi complex.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 178 citations in OpenAlex.
- The Spectrinome: The Interactome of a Scaffold Protein Creating Nuclear and Cytoplasmic Connectivity and Function.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Nuclear mechanical resilience but not stiffness is modulated by αII-spectrin.Journal of biomechanics · 2016Article
- Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.Current biology : CB · 2014Review
- Actin acting at the Golgi.Histochemistry and cell biology · 2013Review
- A single divergent exon inhibits ankyrin-B association with the plasma membrane.The Journal of biological chemistry · 2013Article
- βIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex.The Journal of biological chemistry · 2013Article
- Fodrin in centrosomes: implication of a role of fodrin in the transport of gamma-tubulin complex in brain.PloS one · 2013Article
- Spectrin-based skeleton as an actor in cell signaling.Cellular and molecular life sciences : CMLS · 2012Review
- Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila.The Journal of cell biology · 2010Article
- Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Membrane domains based on ankyrin and spectrin associated with cell-cell interactions.Cold Spring Harbor perspectives in biology · 2009Review
- A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane.Journal of cell science · 2009Article
- Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells.American journal of physiology. Cell physiology · 2008Article
- Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex.Molecular biology of the cell · 2004Article
- Golgi localization of Syne-1.Molecular biology of the cell · 2003Article
- Loss of the F-actin binding and vesicle-associated protein comitin leads to a phagocytosis defect.Eukaryotic cell · 2002Article
- Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP.Molecular biology of the cell · 2002Article
- Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain.The EMBO journal · 2001Article
- cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network.The EMBO journal · 2001Article
- Association of spectrin-like proteins with the actin-organized aggregate of endoplasmic reticulum in the Spitzenkörper of gravitropically tip-growing plant cells.Plant physiology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Spectrin is a major component of a membrane-associated cytoskeleton involved in the maintenance of membrane structural integrity and the generation of functionally distinct membrane protein domains. Here, we show that a homolog of erythrocyte beta-spectrin (beta I sigma*) co-localizes with markers of the Golgi complex in a variety of cell types, and that microinjected beta-spectrin codistributes with elements of the Golgi complex. Significantly, we show a dynamic relationship between beta-spectrin and the structural and functional organization of the Golgi complex. Disruption of both Golgi structure and function, either in mitotic cells or following addition of brefeldin A, is accompanied by loss of beta-spectrin from Golgi membranes and dispersal in the cytoplasm. In contrast, perturbation of Golgi structure without a loss of function, by the addition of nocodazole, results in retention of beta-spectrin with the dispersed Golgi elements. These results indicate that the association of beta-spectrin with Golgi membranes is coupled to Golgi organization and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.