ArticleInfection and immunity1994
Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 177 citations in OpenAlex.
- Plasma-soluble CD30 in childhood tuberculosis: effects of disease severity, nutritional status, and vitamin A therapy.Clinical and diagnostic laboratory immunology · 1999Trial
- Identification of immune biomarkers in recent active pulmonary tuberculosis.Scientific reports · 2023Article
- Value of serum cytokine biomarkers TNF-α, IL-4, sIL-2R and IFN-γ for use in monitoring bacterial load and anti-tuberculosis treatment progress.Cytokine: X · 2020Article
- Article
- A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients.Mediators of inflammation · 2016Article
- The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology.The Journal of pathology · 2014Article
- No association of IFNG+874T/A SNP and NOS2A-954G/C SNP variants with nitric oxide radical serum levels or susceptibility to tuberculosis in a Brazilian population subset.BioMed research international · 2013Article
- Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment.Tuberculosis research and treatment · 2013Article
- Immunology of tuberculosis.World journal of experimental medicine · 2012Article
- γδ T cells cross-link innate and adaptive immunity in Mycobacterium tuberculosis infection.Clinical & developmental immunology · 2011Review
- Human T cell and antibody-mediated responses to the Mycobacterium tuberculosis recombinant 85A, 85B, and ESAT-6 antigens.Clinical & developmental immunology · 2011Article
- Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis.PLoS pathogens · 2010Article
- Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis.Respiration; international review of thoracic diseases · 2010Article
- Evaluation of memory immune response to mycobacterium extract among household contact of tuberculosis cases.Journal of clinical laboratory analysis · 2009Article
- Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Translational mini-review series on vaccines: Development and evaluation of improved vaccines against tuberculosis.Clinical and experimental immunology · 2007Review
- Changes in serum cytokine levels in active tuberculosis with treatment.Mediators of inflammation · 2005Article
- CD69 expression on CD4+ T lymphocytes after in vitro stimulation with tuberculin is an indicator of immune sensitization against Mycobacterium tuberculosis antigens.Clinical and diagnostic laboratory immunology · 2005Article
- T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis.Clinical and experimental immunology · 2003Article
- Influence of Mycobacterium tuberculosis on differential activation of helper T-cells.Clinical and experimental immunology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to determine the profile of immune responsiveness that differentiates patients with tuberculosis (TB) from healthy tuberculin-positive controls. Forty-five patients with pulmonary TB and 16 healthy tuberculin-positive controls, all human immunodeficiency virus negative, were studied. Patients had decreased reactivity to tuberculin, diminished proliferative response to purified protein derivative (PPD), lower concentrations of interleukin-2 (IL-2) and gamma interferon in PPD-stimulated cultures, no increase in the percentage of gamma/delta cells in PPD-stimulated cultures, and higher immunoglobulin G antimycobacterial antibodies compared with control subjects. Furthermore, controls exhibited decreased production of IL-4 by PPD-stimulated cells. Multivariate discriminant and factor analyses demonstrated divergent patterns of immune reactivity against mycobacterial antigens. The association of IL-4 and immunoglobulin G antibody levels in patients, in contrast to the high reactivity to tuberculin, increased proliferation to PPD, and higher levels of IL-2 and gamma interferon observed in healthy controls suggested that most TB patients exhibit a TH2 pattern of immune responsiveness while tuberculin-positive healthy individuals have a TH1 pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.