ArticleInfection and immunity1994
Resistance of Enterococcus faecium to neutrophil-mediated phagocytosis.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 84 citations in OpenAlex.
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- Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci.Infection and immunity · 2019Article
- Group IIA-Secreted Phospholipase AInfection and immunity · 2018Article
- Differential Penicillin-Binding Protein 5 (PBP5) Levels in the Enterococcus faecium Clades with Different Levels of Ampicillin Resistance.Antimicrobial agents and chemotherapy · 2017Article
- Gastrointestinal Tract Colonization Dynamics by Different Enterococcus faecium Clades.The Journal of infectious diseases · 2016Article
- A Vaccine Approach for the Prevention of Infections by Multidrug-resistant Enterococcus faecium.The Journal of biological chemistry · 2015Article
- The high PMNs phagocytosis resistance of enterococcal isolates from RTx patients.BioMed research international · 2015Article
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- Impact of vancomycin resistance on mortality in neutropenic patients with enterococcal bloodstream infection: a retrospective study.BMC infectious diseases · 2013Article
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- Secondary cell wall polymers of Enterococcus faecalis are critical for resistance to complement activation via mannose-binding lectin.The Journal of biological chemistry · 2012Article
- Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes.BMC microbiology · 2012Article
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- Importance of two Enterococcus faecium loci encoding Gls-like proteins for in vitro bile salts stress response and virulence.The Journal of infectious diseases · 2011Article
- Further characterization of the epa gene cluster and Epa polysaccharides of Enterococcus faecalis.Infection and immunity · 2009Article
- Neutrophils are essential for rapid clearance of Enterococcus faecium in mice.Infection and immunity · 2009Article
- New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis.Bioorganic & medicinal chemistry letters · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During a previous study of the opsonic requirements for neutrophil (polymorphonuclear leukocyte [PMN])-mediated killing of enterococci, we identified two strains of Enterococcus faecium (TX0015 and TX0016) that were resistant to PMN-mediated killing. To better define the mechanism of this resistance, we examined phagocytosis with a fluorescence assay and found that TX0016 was completely resistant to phagocytosis by PMNs; this finding was confirmed by electron microscopy. Examination of multiple strains of enterococci revealed that all 20 strains of Enterococcus faecalis tested were readily phagocytosed (mean, 18 intracellular organisms per PMN; range, 7 to 28). In contrast, only 13 (50%) of 26 strains of E. faecium tested were susceptible to phagocytosis (> or = 7 organisms per PMN); the other 13 strains showed < or = 3 organisms per PMN. Enterococcus casseliflavus ATCC 25788 and one strain of Enterococcus hirae were also resistant to phagocytosis, while two strains of Enterococcus durans, Enterococcus mundtii ATCC 43186, and one strain each of Enterococcus raffinosus and Enterococcus solitarius were readily phagocytosed. Exposure of E. faecium TX0016 to sodium periodate, but not to the protease trypsin or pronase or to phospholipase C, eliminated resistance to phagocytosis. Sialic acid, a common periodate-sensitive structure used by microorganisms to resist opsonization, could not be demonstrated in E. faecium TX0016 by the thiobarbituric acid method, nor was phagocytosis of TX0016 altered by neuraminidase treatment. This study suggests that there is a difference in susceptibility to phagocytosis by PMNs between different species of enterococci and that a carbohydrate-containing moiety which is not sialic acid may be involved in the resistance of E. faecium TX0016 to phagocytosis.
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