ArticleGut1994
Localisation of vitamin D receptor in normal human duodenum and in patients with coeliac disease.
Article in Gut, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 58 citations in OpenAlex.
- The Effect of a Gluten-Free Diet on Vitamin D Metabolism in Celiac Disease: The State of the Art.Metabolites · 2023Review
- Analysis of 1,25-Dihydroxyvitamin DMolecular and cellular biology · 2020Article
- Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases.Middle East journal of digestive diseases · 2020Article
- Localization of the 1,25-dihydroxyvitamin d-mediated response in the intestines of mice.The Journal of steroid biochemistry and molecular biology · 2019Article
- Phosphorylation of Human Retinoid X Receptor α at Serine 260 Impairs Its Subcellular Localization, Receptor Interaction, Nuclear Mobility, and 1α,25-Dihydroxyvitamin D3-dependent DNA Binding in Ras-transformed Keratinocytes.The Journal of biological chemistry · 2017Article
- Celiac disease and hepatitis C relationships in transcriptional regulatory networks.Gastroenterology and hepatology from bed to bench · 2017Article
- Increased risk for vitamin d deficiency in obese children with both celiac disease and type 1 diabetes.Gastroenterology research and practice · 2014Article
- Bone mass and mineral metabolism alterations in adult celiac disease: pathophysiology and clinical approach.Nutrients · 2013Review
- The clinical significance of 25OH-Vitamin D status in celiac disease.Clinical reviews in allergy & immunology · 2012Article
- Bone mineralization in celiac disease.Gastroenterology research and practice · 2012Article
- The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2.Journal of cellular physiology · 2009Article
- Bone in celiac disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Review
- Vitamin D status in gastrointestinal and liver disease.Current opinion in gastroenterology · 2008Review
- Calcium absorption and bone mineral density in celiacs after long term treatment with gluten-free diet and adequate calcium intake.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Article
- In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue.The Histochemical journal · 2001Article
- Vitamin D receptor expression in colorectal cancer.Journal of clinical pathology · 1999Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Immunocytochemistry using a specific monoclonal antibody 9A7 gamma was used to identify receptors for calcitriol (1,25 (OH)2 D3), the active metabolite of vitamin D, in sections of duodenal mucosa. Specific staining for vitamin D receptors was largely restricted to nuclei of enterocytes lining crypts in duodenal biopsy specimens from normal mucosa. Vitamin D receptors were also abundant in crypts from duodenal mucosa in coeliac disease patients with mucosal damage and villous atrophy. In contrast, alkaline phosphatase, a vitamin D regulated protein, was absent from crypts but present on brush borders of normal villi, and on surface enterocytes in coeliac disease. Oestrogen receptor could not be identified in duodenal mucosa. These findings suggest that calcium malabsorption in coeliac disease does not result from the absence of vitamin D receptors, but rather from reduction in vitamin D regulated proteins and functions essential for active calcium absorption that are located in the enterocytes of the villi.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.