ArticleGut1994
Interaction of Helicobacter pylori and its fatty acids with parietal cells and gastric H+/K(+)-ATPase.
Article in Gut, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Effectiveness of acid suppression in preventing gastroesophageal reflux disease (GERD) after successful treatment of Helicobacter pylori infection.Digestive diseases and sciences · 2001Trial
- Review
- Review
- Association of Barrett's esophagus withTherapeutic advances in chronic disease · 2022Article
- The Physiology of the Gastric Parietal Cell.Physiological reviews · 2020Review
- Gastric Parietal Cell Physiology and Helicobacter pylori-Induced Disease.Gastroenterology · 2019Review
- Review
- Article
- Article
- Relationship of sliding hiatus hernia to gastroesophageal reflux disease: a possible role for Helicobacter pylori infection?Digestive diseases and sciences · 2003Article
- Effect of purified lipopolysaccharides from strains of Helicobacter pylori and Helicobacter felis on acid secretion in mouse gastric glands in vitro.Infection and immunity · 2001Article
- Article
- Article
- Effects of inflammatory cytokines induced by Helicobacter pylori infection on aminopyrine accumulation in parietal cells isolated from guinea pigs.Digestive diseases and sciences · 1999Article
- Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole.Gut · 1999Article
- Review
- Inhibiting acid and Helicobacter pylori?Gut · 1997Article
- Lipid profile of Helicobacter spp.: presence of cholesteryl glucoside as a characteristic feature.Journal of bacteriology · 1996Article
- Effect of curing Helicobacter pylori infection on intragastric pH during treatment with omeprazole.Gut · 1995Article
- Helicobacter pylori and its interaction with chief and parietal cells.The Yale journal of biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori and the fatty acids produced by this organism were compared for their acid inhibitory activity in isolated parietal cells and their interaction with gastric H+/K(+)-ATPase. H pylori (intact organisms, sonicates, methanolic extracts, and extracts from culture medium) and the fatty acids cis 9,10-methyleneoctadecanoic acid and tetradecanoic acid inhibited at fairly high concentrations histamine- and dibutyryl cyclic adenosine monophosphate stimulated acid production in isolated parietal cells, dissipated (with a slow onset) the H+/K(+)-ATPase created H+ gradient in gastric membrane vesicles, and inhibited H+/K(+)-ATPase activity in a concentration dependent manner. The inhibitory potency of H pylori and the fatty acids in relation to H+/K(+)-ATPase depended on the amount of membrane protein. Bovine serum albumin prevented enzyme inhibition and proton dissipation from gastric vesicles. The data indicate that H pylori establishes its antisecretory action in parietal cells by blocking H+/K(+)-ATPase activity and also by a detergent action at the apical parietal cell membrane. The fatty acids cis 9,10-methyleneoctadecanoic acid and tetradecanoic acid are probably the acid inhibitory factors secreted by H pylori.
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