ArticleGut1994
Ileal and colonic fatty acid profiles in patients with active Crohn's disease.
Article in Gut, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Aged oolong tea alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and its metabolites.Food chemistry: X · 2024Article
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- Colonic mucosal biopsy location can not affect the results of mucosal metabolomics and mucosal microbiota analysis in IBS.Frontiers in medicine · 2023Article
- Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment.Frontiers in immunology · 2023Review
- The Fatty Acid-Based Erythrocyte Membrane Lipidome in Dogs with Chronic Enteropathy.Animals : an open access journal from MDPI · 2021Article
- The Mediterranean diet: effects on proteins that mediate fatty acid metabolism in the colon.Nutrition reviews · 2011Review
- New insights into the role of fatty acids in the pathogenesis and resolution of inflammatory bowel disease.Inflammatory bowel diseases · 2011Review
- Crohn's disease: evidence for involvement of unregulated transcytosis in disease etio-pathogenesis.World journal of gastroenterology · 2011Review
- Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice.Journal of lipid research · 2010Article
- Article
- Lipoprotein docosapentaenoic acid is associated with serum matrix metalloproteinase-9 concentration.Lipids in health and disease · 2005Article
- Changes in plasma and colonic mucosa fatty acid profiles in rats with ulcerative colitis induced by trinitrobenzene sulfonic acid.Digestive diseases and sciences · 1998Article
- Plasma and mucosal fatty acid pattern in colectomized ulcerative colitis patients.Digestive diseases and sciences · 1998Article
- Serum n3 polyunsaturated fatty acids are depleted in Crohn's disease.Digestive diseases and sciences · 1997Article
- Influence of heated and nonheated partially hydrogenated dietary fats on ileal chyme fat and fatty acid composition of ileal mucosa in pigs.Digestive diseases and sciences · 1995Article
- [What is the role of nutrition in ulcerative colitis? A contribution to the current status of diet therapy in treatment of inflammatory bowel diseases].Langenbecks Archiv fur Chirurgie · 1995Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with active Crohn's disease and in a control group the fatty acid profiles in the whole lipid fraction of ileal and colonic mucosal biopsy specimens were determined by capillary gas chromatography. The biopsy specimens in Crohn's disease patients were taken from the inflamed terminal ileum as well as from the inflamed and macroscopically normal colon. Compared with controls the fatty acid distribution in the inflamed ileal mucosa was significantly characterised by (a) a decrease of 18:2 n6 and 18:3 n3 accompanied by a substantial increase of the highly polyunsaturated fatty acids 20:4 n6, 22:4 n6, and 22:6 n3 and (b) a higher unsaturation index of total fatty acids compared with controls. These changes were similar in the inflamed colon. Additionally, both the inflamed and the macroscopically normal colonic mucosa showed an increase of saturated (18:0) and a decrease of monounsaturated fatty acids (18:1 n9). Fatty acid profiles of ileum and colon showed side variations in controls, but not in the Crohn's disease group. These data suggest that in Crohn's disease changes in the distribution of polyunsaturated fatty acids seem to be the general feature of inflamed mucosa in small and large intestine. Results further suggest that colonic fatty acid metabolism in Crohn's disease is altered by degrees, showing changes in saturated and monounsaturated fatty acids as an additional, primary event.
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