Trial reportEuropean journal of applied physiology and occupational physiology1994
Effect of infusing branched-chain amino acid during incremental exercise with reduced muscle glycogen content.
Trial report in European journal of applied physiology and occupational physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 70 citations in OpenAlex.
- Effects of dietary leucine supplementation on exercise performance.European journal of applied physiology · 2006Trial
- Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Review
- Changes in Serum Free Amino Acids and Muscle Fatigue Experienced during a Half-Ironman Triathlon.PloS one · 2015Article
- Is it time to turn our attention toward central mechanisms for post-exertional recovery strategies and performance?Frontiers in physiology · 2015Review
- Dietary supplements and team-sport performance.Sports medicine (Auckland, N.Z.) · 2010Review
- Fatigue in tennis: mechanisms of fatigue and effect on performance.Sports medicine (Auckland, N.Z.) · 2007Review
- Central fatigue: the serotonin hypothesis and beyond.Sports medicine (Auckland, N.Z.) · 2006Review
- Biochemical aspects of overtraining in endurance sports: a review.Sports medicine (Auckland, N.Z.) · 2002Review
- Leucine supplementation and intensive training.Sports medicine (Auckland, N.Z.) · 1999Review
- Nutrition for improved sports performance. Current issues on ergogenic aids.Sports medicine (Auckland, N.Z.) · 1996Review
- The effect of endurance training on regional serotonin metabolism in the brain during early stage of detraining period in the female rat.Cellular and molecular neurobiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate whether, when muscle glycogen is reduced, a pre-exercise infusion of branched-chain amino acids (BCAA) modifies exercise performance or the metabolic and respiratory responses to incremental exercise. Six moderately trained volunteers took part in the following protocol on two occasions. On day 1, at 9 a.m. in the postabsorptive state, they performed a graded incremental exercise (increases of 35 W every 4 min) to exhaustion (Ex-1). A meal of 1,000 kcal (4,200 kJ; 60% protein, 40% fat) was consumed at 12 p.m. No food was then allowed until the end of the experiment (20-21 h later). A 90-min period of exercise at alternating high and moderate intensities, designed to deplete muscle glycogen, was performed between 6 p.m. and 7.30 p.m. The morning after (day 2), the subjects randomly received either a mixed solution of BCAA (260 mg x kg-1 x h-1 for 70 min), or saline. They then repeated the graded incremental exercise to exhaustion (Ex-2). Metabolic and respiratory measurements suggested a muscle glycogen-depleted state had been achieved. No significant differences were observed in total work performed, maximal oxygen uptake or plasma ammonia, alanine, and blood pyruvate concentrations in the two treatments. After BCAA infusion, higher blood lactate concentrations were observed at maximal power output in comparison with those during saline [BCAA 4.97 (SEM 0.41) mmol x l-1, Saline 3.88 (SEM 0.47) mmol x l-1, P < 0.05].(ABSTRACT TRUNCATED AT 250 WORDS)
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.