ArticleThe EMBO journal1994
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed, 355 citations in OpenAlex.
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- Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL.Cell death and differentiation · 2022Article
- Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity.Nutrients · 2021Review
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- Reduced DNA methylation and psychopathology following endogenous hypercortisolism - a genome-wide study.Scientific reports · 2017Article
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- Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.International journal of molecular sciences · 2015Review
- The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.PloS one · 2014Article
- Review
- The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans.PloS one · 2010Article
- The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversification.Development (Cambridge, England) · 2009Article
- Function of retinoic acid receptors during embryonic development.Nuclear receptor signaling · 2009Review
- c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation.Oncogene · 2006Article
- The tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryo.Molecular and cellular biology · 2006Article
- Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.Molecular and cellular biology · 2005Article
- Unique functional properties of a member of the Fushi Tarazu-Factor 1 family from Schistosoma mansoni.The Biochemical journal · 2004Article
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- X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.Molecular and cellular biology · 2001Article
- The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.Genes & development · 2001Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A motif essential for the transcriptional activation function 2 (AF-2) present in the E region of retinoic acid receptor (RAR) alpha and 9-cis retinoic acid receptor (RXR) alpha has been characterized as an amphipathic alpha-helix whose main features are conserved between transcriptionally active members of the nuclear receptor superfamily. This conserved motif, which can activate autonomously in the absence of ligand in animal and yeast cells, can be swapped between nuclear receptors without affecting the ligand dependency for activation of transcription, thus indicating that a ligand-dependent conformational change is necessary to reveal the AF-2 activation potential within the E region of the nuclear receptor. Interestingly, we show that the precise nature of the direct repeat response element to which RAR/RXR heterodimers are bound can affect the activity of the AF-2s of the heterodimeric partners, as well as the relative efficiency with which all-trans and 9-cis retinoic acids activate the RAR partner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.