ArticleThe EMBO journal1994
Premature chromatin condensation upon accumulation of NIMA.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 132 citations in OpenAlex.
- Prognostic value and therapeutic potential of NEK family in stomach adenocarcinoma.Journal of Cancer · 2024Article
- Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo.Oncotarget · 2016Article
- The Set1/COMPASS histone H3 methyltransferase helps regulate mitosis with the CDK1 and NIMA mitotic kinases in Aspergillus nidulans.Genetics · 2014Article
- Identification of interphase functions for the NIMA kinase involving microtubules and the ESCRT pathway.PLoS genetics · 2014Article
- The NIMA kinase is required to execute stage-specific mitotic functions after initiation of mitosis.Eukaryotic cell · 2014Article
- Article
- Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Molecular biology of the cell · 2013Article
- Cell cycle regulation by the NEK family of protein kinases.Journal of cell science · 2012Review
- Nek family of kinases in cell cycle, checkpoint control and cancer.Cell division · 2011Article
- A BEN-domain-containing protein associates with heterochromatin and represses transcription.Journal of cell science · 2011Article
- Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements.Histochemistry and cell biology · 2011Article
- Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability.Molecular cancer · 2011Article
- The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons.Journal of cell science · 2009Article
- Orchestrating nuclear envelope disassembly and reassembly during mitosis.Nature reviews. Molecular cell biology · 2009Review
- Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control.Cell cycle (Georgetown, Tex.) · 2008Article
- Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.Journal of the American Society of Nephrology : JASN · 2008Article
- Mitotic regulation by NIMA-related kinases.Cell division · 2007Article
- Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly.Molecular biology of the cell · 2005Article
- Coordination of DNA damage responses via the Smc5/Smc6 complex.Molecular and cellular biology · 2004Article
- TINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrest.Molecular biology of the cell · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NIMA protein kinase of Aspergillus nidulans is required for the G2/M transition of the cell cycle. Mutants lacking NIMA arrest without morphological characteristics of mitosis, but they do contain an activated p37nimX kinase (the Aspergillus homologue of p34cdc2). To gain a better understanding of NIMA function we have investigated the effects of expressing various NIMA constructs in Aspergillus, fission yeast and human cells. Our experiments have shown that the instability of the NIMA protein requires sequences in the non-catalytic C-terminus of the protein. Removal of this domain results in a stable protein that, once accumulated, promotes a lethal premature condensation of chromatin without any other aspects of mitosis. Similar effects were also observed in fission yeast and human cells accumulating Aspergillus NIMA. This phenotype is independent of cell cycle progression and does not require p34cdc2 kinase activity. As gain of NIMA function by accumulation results in premature chromatin condensation, and loss of NIMA function results in an inability to enter mitosis, we propose that NIMA functions in G2 to promote the condensation of chromatin normally associated with entry into mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.