ArticleClinical and experimental immunology1994
Histamine induces IL-6 production by human endothelial cells.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Strategies to attenuate maladaptive inflammatory response associated with cardiopulmonary bypass.Frontiers in surgery · 2024Review
- Role of Histamine in Modulating the Immune Response and Inflammation.Mediators of inflammation · 2018Review
- Cellular and Oxidative Mechanisms Associated with Interleukin-6 Signaling in the Vasculature.International journal of molecular sciences · 2017Review
- Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis.Intensive care medicine experimental · 2016Article
- Expression and function of histamine and its receptors in atopic dermatitis.Molecular and cellular pediatrics · 2015Article
- A solute carrier family 22 member 3 variant rs3088442 G→A associated with coronary heart disease inhibits lipopolysaccharide-induced inflammatory response.The Journal of biological chemistry · 2015Article
- Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts.Allergy, asthma & immunology research · 2014Article
- An evolving new paradigm: endothelial cells--conditional innate immune cells.Journal of hematology & oncology · 2013Review
- Histamine induces activation of protein kinase D that mediates tissue factor expression and activity in human aortic smooth muscle cells.American journal of physiology. Heart and circulatory physiology · 2012Article
- Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis.BMC medicine · 2012Review
- Overview on the pathomechanisms of allergic rhinitis.Asia Pacific allergy · 2011Article
- Lipopolysaccharide induces H1 receptor expression and enhances histamine responsiveness in human coronary artery endothelial cells.Immunology · 2011Article
- Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cdelta-dependent ERK activation pathway.The Journal of biological chemistry · 2008Article
- Histamine directly and synergistically with lipopolysaccharide stimulates cyclooxygenase-2 expression and prostaglandin I(2) and E(2) production in human coronary artery endothelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Article
- Article
- Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors.British journal of pharmacology · 2001Article
- Interleukin-6 expression by cultured human endothelial cells in contact with carbon coated polyethylene terephthalate.Journal of materials science. Materials in medicine · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histamine is one of the major mediators implicated in the physiopathology of allergy. On vascular endothelium, histamine mainly induces early effects: an increase in vasopermeability leading to oedema, a release of lipid mediators and a transient expression of P-selectin. The aim of this study was to evaluate the effects of histamine on adhesion molecule expression and IL-6 production by human endothelial cells. Histamine did not modulate the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, but induced a transient expression of P-selectin as previously reported. In addition, histamine increased in a dose- (from 10(-5) to 10(-3) M) and time- (from 4 h to 24 h) dependent fashion the IL-6 synthesis by endothelial cells. Tumour necrosis factor-alpha (TNF-alpha)-induced IL-6 production was also potentiated in a dose-dependent manner by histamine, without modification of the time course of IL-6 secretion. Moreover, this increase of IL-6 production induced by histamine was inhibited in a dose-dependent manner by H1 and H2 histamine receptor antagonists (50% inhibition of IL-6 production at 5 x 10(-4) M and 4 x 10(-5) M, respectively). So, histamine induces, besides already well known effects, a late stimulation of endothelial cells, i.e. the production of IL-6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.