Evidence map›Paper›PMID 7949733›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society1994

Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences.

P Sanséau, A Jackson, R P Alderton, S Beck, G Senger, D Sheer, A Kelly, J Trowsdale

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

P SanséauICRF, Human Immunogenetics, London, UK.
A Jackson
R P Alderton
S Beck
G Senger
D Sheer
A Kelly
J Trowsdale
The Honourable Society of Lincoln's Inn · GB

Funding

Cancer Research UK A3585
6 · The paper itself

Abstract

cDNA clones similar to rabbit muscle phosphatase inhibitor-2 (IPP-2) were isolated from human libraries. On Northern blots two transcripts of approximately 2kbp and approximately 4kbp were detected in all tissues tested. Analysis of cDNA sequences showed that the longer transcripts were similar to the shorter clones but contained extended 3' ends. The human nucleotide sequence was highly homologous (94% identity) to the rabbit IPP-2 sequence and encoded a peptide of 205 amino acids. IPP-2 sequences were highly conserved throughout vertebrates. Southern hybridization results were consistent with the existence of a family of related IPP-2 sequences in the human genome. Most of these are likely to be pseudogenes, since all of the cDNA clones examined could have originated from a single gene. By in situ hybridization IPP-2 sequences were mapped to several different human chromosomes. We sequenced one gene located in the major histocompatibility complex (MHC) on Chromosome (Chr) 6 that contained the entire coding region of IPP-2.

Indexed as

Amino Acid SequenceAnimalsBase SequenceChromosome MappingChromosomes, Human, Pair 6Cloning, MolecularDNA, ComplementaryGenes, fosGenes, MHC Class IIHumansIn Situ HybridizationMolecular Sequence DataMuscle ProteinsPhosphoprotein PhosphatasesProtein Phosphatase Inhibitory ProteinsProteinsDNA, ComplementaryMuscle ProteinsPhosphoprotein Phosphatasesprotein phosphatase inhibitor-2Protein Phosphatase Inhibitory ProteinsProteins

Identifiers

PMID7949733
OpenAlexW2070948034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.