ArticlePediatric nephrology (Berlin, Germany)1994
Effect of cyclosporin A on glomerular filtration rate in children with minimal change nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Mycophenolate mofetil versus cyclosporine for remission maintenance in nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2008Trial
- Frequently relapsing nephrotic syndrome: treatment with mycophenolate mofetil.Pediatric nephrology (Berlin, Germany) · 2004Trial
- Infrequent tacrolimus-induced nephrotoxicity in French patients with steroid-dependent nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2019Observational
- Pathogenesis and Management of Acute Kidney Injury in Patients with Nephrotic Syndrome Due to Primary Glomerulopathies.Medicina (Kaunas, Lithuania) · 2019Review
- Calcineurin inhibitor induced nephrotoxicity in steroid resistant nephrotic syndrome.Indian journal of nephrology · 2013Article
- Management patterns of childhood-onset nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2009Article
- Experience with tacrolimus in children with steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2009Article
- Cyclosporine-A-induced nephrotoxicity in children with minimal-change nephrotic syndrome: long-term treatment up to 10 years.Pediatric nephrology (Berlin, Germany) · 2008Article
- Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome.Archives of disease in childhood · 1994Article
- Long-term cyclosporin A treatment of minimal-change nephrotic syndrome of childhood.Pediatric nephrology (Berlin, Germany) · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclosporin A (CyA) is now commonly used in the management of children with steroid-dependent nephrotic syndrome. In order to assess nephrotoxicity related to CyA therapy, we measured glomerular filtration rate (GFR) on 123 occasions in 24 children with minimal change nephrotic syndrome receiving CyA. GFR was estimated from the plasma clearance of 51chromium-EDTA every 3 months during CyA therapy of up to 27 months duration. There was a significant reduction in GFR after 3 months of CyA therapy [118 +/- 33 (SD) to 93 +/- 24 ml/min per 1.73 m2] but no further fall thereafter, although the reduction in GFR was sustained for the duration of CyA therapy. This reduction in GFR appeared to be reversible upon cessation of CyA, but careful monitoring of renal function is necessary in such patients to prevent the development of longer term nephrotoxic sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.