ArticlePediatric nephrology (Berlin, Germany)1994
Long-term cyclosporin A treatment of minimal-change nephrotic syndrome of childhood.
Article in Pediatric nephrology (Berlin, Germany), 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment of steroid-sensitive nephrotic syndrome: new guidelines from KDIGO.Pediatric nephrology (Berlin, Germany) · 2013Guideline
- Two-year follow-up of a prospective clinical trial of cyclosporine for frequently relapsing nephrotic syndrome in children.Clinical journal of the American Society of Nephrology : CJASN · 2012Trial
- Nephrotoxicity of once-daily cyclosporine A in minimal change nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2012Trial
- Adrenocortical suppression increases the risk of relapse in nephrotic syndrome.Archives of disease in childhood · 2007Trial
- Factors associated with chronic calcineurin inhibitor nephrotoxicity in children with minimal-change disease.Renal failure · 2025Article
- Cost analysis on the use of rituximab and calcineurin inhibitors in children and adolescents with steroid-dependent nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2018Article
- Effects of cyclosporine on bone mineral density in patients with glucocorticoid-dependent nephrotic syndrome in remission.International urology and nephrology · 2013Article
- Chapter 3: Steroid-sensitive nephrotic syndrome in children.Kidney international supplements · 2012Article
- New therapies in steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2011Review
- Single daily high-dose mizoribine therapy for children with steroid-dependent nephrotic syndrome prior to cyclosporine administration.Pediatric nephrology (Berlin, Germany) · 2011Article
- Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment.Pediatric nephrology (Berlin, Germany) · 2009Article
- Cyclosporine-A-induced nephrotoxicity in children with minimal-change nephrotic syndrome: long-term treatment up to 10 years.Pediatric nephrology (Berlin, Germany) · 2008Article
- Does cyclosporine achieve a real advantage for treatment of idiopathic nephrotic syndrome in children? A long-term efficacy and safety study.International urology and nephrology · 2007Article
- High-dose mizoribine therapy for childhood-onset frequently relapsing steroid-dependent nephrotic syndrome with cyclosporin nephrotoxicity.Pediatric nephrology (Berlin, Germany) · 2005Article
- Treatment of steroid sensitive nephrotic syndrome.Indian journal of pediatrics · 2005Review
- Single-dose daily administration of cyclosporin A for relapsing nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2004Article
- The management of idiopathic nephrotic syndrome in children.Paediatric drugs · 2003Review
- Steroid sensitive nephrotic syndrome.Indian journal of pediatrics · 2002Review
- Cyclosporin A therapy in refractory non-infectious childhood uveitis.The British journal of ophthalmology · 1998Article
- Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome.Archives of disease in childhood · 1994Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the efficacy of long-term cyclosporin A (CyA) treatment in the maintenance of remission in 40 children with steroid-dependent minimal-change nephrotic syndrome (MCNS). CyA was given in an initial dose of 5 mg/kg per day, adjusted to maintain a trough whole blood level of 50-150 ng/ml. All the 40 children received CyA for 1 year. In 18 patients, CyA was continued for a further period of at least a year without interruption; 9 patients had a second course of CyA therapy after an interval of at least 1 month. Of the 40 children 29 (72%) had one or more relapses during treatment with CyA, with 16 (40%) relapsing during the 1st year. During the second period of CyA, 10 (56%) of the 18 children treated continuously relapsed, whereas all the 9 children who had an interrupted course of therapy relapsed. CyA was discontinued at one time in 27 patients, all of whom subsequently relapsed, with a median time to relapse of 26 days. Long-term prednisolone in addition to CyA was required to maintain remission in 16 (40%) of the whole group. The results suggest that the long-term use of CyA is able to maintain remission of MCNS, although 40% of the patients also required low-dose alternate-day steroids; patients appeared to fare worse if the CyA course was interrupted; no patient experienced a long-term remission after CyA was stopped.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.