ArticleAnnals of surgery1994
Bombesin improves survival from methotrexate-induced enterocolitis.
Article in Annals of surgery, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats.World journal of gastroenterology · 2008Article
- Stimulating effect of Japanese herbal (kampo) medicine, hochuekkito on upper respiratory mucosal immune system.Evidence-based complementary and alternative medicine : eCAM · 2006Article
- Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006Review
- Gastrin releasing peptide receptor expression is decreased in patients with Crohn's disease but not in ulcerative colitis.Journal of clinical pathology · 2004Article
- Protective effect of enriched diet plus growth hormone administration on radiation-induced intestinal injury and on its evolutionary pattern in the rat.Digestive diseases and sciences · 1999Article
- Bombesin ameliorates colonic damage in experimental colitis.Digestive diseases and sciences · 1999Article
- Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk.Applied and environmental microbiology · 1995Article
- Role of bombesin on gut mucosal growth.Annals of surgery · 1995Article
- Bombesin stimulates mucosal growth in jejunal and ileal Thiry-Vella fistulas.Annals of surgery · 1995Article
- Glucagon-like peptide 2 is a potent growth factor for small intestine and colon.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
- Enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary TractArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors determined whether bombesin could improve survival from methotrexate (MTX)-induced enterocolitis. SUMMARY BACKGROUND DATA: Bombesin prevents gut mucosal atrophy, which is produced by feeding rats an elemental diet. Administration of MTX produces a lethal enterocolitis in rats fed an elemental diet.
methodsOn treatment day 0, 60 rats were divided randomly into three groups and fed an elemental diet (Vivonex TEN, Sandoz, Minneapolis, MN) as the only source of nutrition. Groups were subdivided further to receive either saline or bombesin (10 micrograms/kg, subcutaneously, three times a day) beginning either on day 0 or day 14. Methotrexate (20 mg/kg, intraperitoneally) was given to all rats 14 days after the start of an elemental diet.
resultsBombesin prevented the mucosal atrophy in the ileum produced by the elemental diet and significantly decreased mortality in rats given MTX (whether given as a pretreatment or at the time of MTX administration).
conclusionBombesin significantly improved survival in a lethal model of MTX-induced enterocolitis, possibly by maintaining gut mucosal structure. Administration of bombesin to patients receiving chemotherapy may be clinically useful in preventing the severe enterocolitis induced by various chemotherapeutic agents.
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Registered trials
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