ArticleThe American journal of pathology1994
Regulation of Mel-CAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 125 citations in OpenAlex.
- Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation.bioRxiv : the preprint server for biology · 2024Article
- Review
- GABA Regulates Electrical Activity and Tumor Initiation in Melanoma.Cancer discovery · 2023Article
- METCAM Is a Potential Biomarker for Predicting the Malignant Propensity of and as a Therapeutic Target for Prostate Cancer.Biomedicines · 2023Review
- Melanocyte-keratinocyte cross-talk in vitiligo.Frontiers in medicine · 2023Review
- Article
- Stromal Cells Present in the Melanoma Niche Affect Tumor Invasiveness and Its Resistance to Therapy.International journal of molecular sciences · 2021Review
- Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.Neoplasia (New York, N.Y.) · 2019Article
- The Prevalence of CD146 Expression in Breast Cancer Subtypes and Its Relation to Outcome.Cancers · 2018Article
- Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior.eLife · 2018Article
- Stem Cell Pathology.Annual review of pathology · 2018Review
- Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state.Stem cell research & therapy · 2017Article
- Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma.The Journal of investigative dermatology · 2017Article
- Crosstalk in skin: melanocytes, keratinocytes, stem cells, and melanoma.Journal of cell communication and signaling · 2016Review
- Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo.The Journal of biological chemistry · 2014Article
- CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer.Oncology letters · 2013Article
- Evaluation of a multi-marker immunomagnetic enrichment assay for the quantification of circulating melanoma cells.Journal of translational medicine · 2012Article
- Dual Roles of METCAM in the Progression of Different Cancers.Journal of oncology · 2012Article
- Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma.Cancer research · 2009Article
- CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines.Breast cancer research : BCR · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cell-cell adhesion receptor, Mel-CAM/MUC18, is highly expressed on metastatic melanoma cells and is also detectable on primary melanomas but not on normal melanocytes. Previous studies have shown that increased Mel-CAM/MUC18 expression correlates with tumor thickness and metastatic potential. We show here that normal melanocytes and nevus cells in culture express Mel-CAM/MUC18, but expression is down-regulated when cells are co-cultured with keratinocytes. Such keratinocyte-mediated regulation of Mel-CAM/MUC18 expression on melanocytes, nevus cells, and early melanomas can also be demonstrated in situ in patients' specimens. On the other hand, melanoma cells from primary and metastatic lesions constitutively express Mel-CAM/MUC18, and keratinocytes have no modulatory effect. These results suggest that contact between keratinocytes and human melanocytic cells modulates Mel-CAM/MUC18 expression, raising the possibility that escape from keratinocyte control during melanoma development leads to expression of antigens that contribute to the malignant phenotype.
Indexed as
Identifiers
7943174PMC1887332W337032861What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.