ArticleProceedings of the National Academy of Sciences of the United States of America1994
Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 109 citations in OpenAlex.
- Antioxidants for Early Treatment of Type 2 Diabetes in Rodents and Humans: Lost in Translation?Diabetes · 2024Review
- Context-dependent effects of CCN2 on β-cell mass expansion and indicators of cell stress in the setting of acute and chronic stress.American journal of physiology. Endocrinology and metabolism · 2023Article
- Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function.Function (Oxford, England) · 2022Article
- Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.The Journal of biological chemistry · 2019Article
- Pancreatic β-cells detoxify HThe Journal of biological chemistry · 2019Article
- Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo.Prostaglandins & other lipid mediators · 2018Article
- Selenium and diabetes--evidence from animal studies.Free radical biology & medicine · 2013Review
- Protective effects of Quercus salicina on alloxan-induced oxidative stress in HIT-T15 pancreatic β cells.Experimental and therapeutic medicine · 2013Article
- Neutraceutical approaches to control diabetes: A natural requisite approach.Journal of natural science, biology, and medicine · 2012Article
- Two tales of antioxidant enzymes on β cells and diabetes.Antioxidants & redox signaling · 2011Review
- Evaluation of the antiradical activity of Schisandra chinensis lignans using different experimental models.Molecules (Basel, Switzerland) · 2010Article
- beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice.Endocrinology · 2009Article
- A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The nature of antioxidant defense mechanisms: a lesson from transgenic studies.Environmental health perspectives · 1998Review
- Article
- Rapid fluorescence in situ hybridization on interphasic nuclei to discriminate between homozygous and heterozygous transgenic mice.Transgenic research · 1996Article
- Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- An elevated level of copper zinc superoxide dismutase fails to prevent oxygen induced retinopathy in mice.The British journal of ophthalmology · 1996Article
- Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.The EMBO journal · 1995Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
A growing body of evidence suggests that active oxygen is an important participant in the destruction of the pancreatic beta cell, which, in turn, leads to type I or insulin-dependent diabetes mellitus. Consequently, genetic factors predisposing susceptibility to insulin-dependent diabetes mellitus may include those that determine active oxygen metabolism. A direct test of this hypothesis is provided by a transgenic model for increased activity of Cu/Zn superoxide dismutase (EC 1.15.1.1), a principal radical scavenging enzyme. Here we demonstrate that elevated levels of this enzyme provided by a Cu/Zn superoxide dismutase transgene enhance the tolerance of pancreatic beta cells to oxidative stress-induced diabetogenesis. These results show that this transgenic approach holds promise for revealing the role of reactive oxygen in autoimmune models of diabetogenesis as well as in other models of disease pathology in which active oxygen has been implicated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.