ArticleProceedings of the National Academy of Sciences of the United States of America1994
A determination of the frequency of gene conversion in unmanipulated mouse sperm.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The role of MHC supertypes in promoting trans-species polymorphism remains an open question.Nature communications · 2018Article
- Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (Frontiers in zoology · 2018Article
- Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA.Genome research · 2012Article
- Recombination-associated sequence homogenization of neighboring Alu elements: signature of nonallelic gene conversion.Molecular biology and evolution · 2010Article
- Variation in patterns of human meiotic recombination.Genome dynamics · 2009Review
- Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations.BMC genomics · 2008Article
- Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles.Immunogenetics · 2007Article
- Inter- and intralocus recombination drive MHC class IIB gene diversification in a teleost, the three-spined stickleback Gasterosteus aculeatus.Journal of molecular evolution · 2005Article
- Concerted and birth-and-death evolution of multigene families.Annual review of genetics · 2005Review
- Recent duplication and inter-locus gene conversion in major histocompatibility class II genes in a teleost, the three-spined stickleback.Immunogenetics · 2004Article
- Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved.American journal of human genetics · 2003Review
- Factors affecting ectopic gene conversion in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Gene conversion of major histocompatibility complex genes in the mouse spermatogenesis is a premeiotic event.Molecular biology of the cell · 1997Article
- Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2).Journal of molecular evolution · 1995Article
- Gene conversions and unequal crossovers between CYP21 (steroid 21-hydroxylase gene) and CYP21P involve different mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- High-frequency gene conversion between repeated C mu sequences integrated at the chromosomal immunoglobulin mu locus in mouse hybridoma cells.Molecular and cellular biology · 1995Article
- Balancing selection and MHC.GeneticaReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene conversion, sometimes also called micro gene conversion or gene conversion-like events, has been proposed to act on a number of genes in higher eukaryotes, such as gamma-globin, beta-tubulin, major urinary protein, and amyloid A genes. In the immune system, immunoglobulin genes and major histocompatibility complex class I and class II genes have been implicated. The notion that integral segments of DNA have been transferred from one gene to another in these cases has, however, met considerable resistance. We have devised a PCR assay detecting only the molecule that results if the E beta d-derived fragment analogous to that introduced in the bm12 mutation is transferred to the A beta k gene. We have proceeded to analyze sperm from the F1 cross C3H/HeJ (haplotype k) x BALB/c (haplotype d). In our assay, we find that the frequency for conversion of this particular DNA segment is 2 x 10(-6). This frequency is relevant only in the germ line; when liver cells were tested as an example of somatic cells, no events were observed, implying a frequency of < 2 x 10(-8) in liver. Fragments > 100 bp seem to be possible to transfer in this conversion.
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