ArticleProceedings of the National Academy of Sciences of the United States of America1994
Molecular structure and chromosomal mapping of the human homolog of the agouti gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 160 citations in OpenAlex.
- Changes in agouti-related protein and symptom improvement in drug-naïve Chinese female patients with anorexia nervosa: a 6-month real-world longitudinal study.Journal of eating disorders · 2026Article
- MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair.International journal of molecular sciences · 2018Review
- BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2017Article
- Melanocortin 1 Receptor: Structure, Function, and Regulation.Frontiers in genetics · 2016Review
- Effects of post-weaning diet on metabolic parameters and DNA methylation status of the cryptic promoter in the A(vy) allele of viable yellow mice.The Journal of nutritional biochemistry · 2015Article
- Neural melanocortin receptors in obesity and related metabolic disorders.Biochimica et biophysica acta · 2014Review
- Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization.PloS one · 2012Article
- Biology of obesity: lessons from animal models of obesity.Journal of biomedicine & biotechnology · 2011Review
- A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep.Genome research · 2008Article
- Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.Bioorganic & medicinal chemistry letters · 2006Article
- Alu-mediated 100-kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes.Genome research · 2006Article
- The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Sequences associated with human iris pigmentation.Genetics · 2003Review
- Review
- A polymorphism in the agouti signaling protein gene is associated with human pigmentation.American journal of human genetics · 2002Article
- Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus.Genetics · 2002Article
- Ribozymes that cleave reovirus genome segment S1 also protect cells from pathogenesis caused by reovirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- In vitro-selected RNA cleaving DNA enzymes from a combinatorial library are potent inhibitors of HIV-1 gene expression.The Biochemical journal · 2000Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The agouti (a) locus in mouse chromosome 2 normally regulates coat color pigmentation. The mouse agouti gene was recently cloned and shown to encode a distinctive 131-amino acid protein with a consensus signal peptide. Here we describe the cloning of the human homolog of the mouse agouti gene using an interspecies DNA-hybridization approach. Sequence analysis revealed that the coding region of the human agouti gene is 85% identical to the mouse gene and has the potential to encode a protein of 132 amino acids with a consensus signal peptide. Chromosomal assignment using somatic-cell-hybrid mapping panels and fluorescence in situ hybridization demonstrated that the human agouti gene maps to chromosome band 20q11.2. This result revealed that the human agouti gene is closely linked to several traits, including a locus called MODY (for maturity onset diabetes of the young) and another region that is associated with the development of myeloid leukemia. Initial expression studies with RNA from several adult human tissues showed that the human agouti gene is expressed in adipose tissue and testis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.