ArticleProceedings of the National Academy of Sciences of the United States of America1994
E1 protein of human papillomavirus type 1a is sufficient for initiation of viral DNA replication.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- Ring-shaped replicative helicase encircles double-stranded DNA during unwinding.Nucleic acids research · 2019Article
- E2 protein is the major determinant of specificity at the human papillomavirus origin of replication.PloS one · 2019Article
- Interaction of NCOR/SMRT Repressor Complexes with Papillomavirus E8^E2C Proteins Inhibits Viral Replication.PLoS pathogens · 2016Article
- The E1 proteins.Virology · 2013Review
- Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.Journal of virology · 2013Article
- Targeting human papillomavirus genome replication for antiviral drug discovery.Antiviral therapy · 2013Review
- Replication and partitioning of papillomavirus genomes.Advances in virus research · 2008Review
- Cellular topoisomerase I modulates origin binding by bovine papillomavirus type 1 E1.Journal of virology · 2006Article
- Identification of cis-acting elements that mediate the replication and maintenance of human papillomavirus type 16 genomes in Saccharomyces cerevisiae.Journal of virology · 2005Article
- mRNA splicing regulates human papillomavirus type 11 E1 protein production and DNA replication.Journal of virology · 2003Article
- Long-term effect of interferon on keratinocytes that maintain human papillomavirus type 31.Journal of virology · 2002Article
- Papillomavirus E1 proteins: form, function, and features.Virus genes · 2002Review
- Human papillomavirus type 31 replication modes during the early phases of the viral life cycle depend on transcriptional and posttranscriptional regulation of E1 and E2 expression.Journal of virology · 2002Article
- The E1 initiator recognizes multiple overlapping sites in the papillomavirus origin of DNA replication.Journal of virology · 2001Article
- Development of human papillomavirus plasmids capable of episomal replication in human cell lines.Gene therapy · 1999Article
- Interactions of the papovavirus DNA replication initiator proteins, bovine papillomavirus type 1 E1 and simian virus 40 large T antigen, with human replication protein A.Journal of virology · 1999Article
- A fifteen-amino-acid peptide inhibits human papillomavirus E1-E2 interaction and human papillomavirus DNA replication in vitro.Journal of virology · 1998Article
- A C-terminal helicase domain of the human papillomavirus E1 protein binds E2 and the DNA polymerase alpha-primase p68 subunit.Journal of virology · 1998Article
- Transcription factor YY1 represses cell-free replication from human papillomavirus origins.Journal of virology · 1998Article
- The carboxyl-terminal region of the human papillomavirus type 16 E1 protein determines E2 protein specificity during DNA replication.Journal of virology · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies on transient replication of papillomaviruses have shown an absolute requirement for the viral E1 and E2 proteins in DNA replication. Here we demonstrate that for human papillomavirus type 1a (HPV-1a) DNA, the E1 protein alone is sufficient for in vivo replication of plasmids containing the viral origin of replication. Replication was origin-specific and required the presence of a DNA sequence containing a putative E1 binding site, but the E2 binding sites were dispensable. In the presence of the E1 protein, E2 stimulated replication of plasmids containing the E1 and E2 binding sites, but no stimulation was observed when the origin plasmids lacked E2 binding sites. Conversely, in the presence of E1 alone, the E2 binding sites did not affect replication. Plasmids containing the replication origins of HPV-6b, HPV-18, and bovine papillomavirus type 1 (BPV-1) also replicated efficiently in the presence of the HPV-1a E1 and E2 proteins. However, plasmids containing the origins of HPV-6b and HPV-18 failed to replicate in the presence of HPV-1a E1 alone, whereas a plasmid containing the BPV-1 origin replicated to lower levels than the HPV-1a origin-containing plasmid. These results suggest that replication from papillomaviral origins in the presence of E1 alone is presumably dependent on the strength of E1-origin interactions. Additionally, E1-dependent replication is stimulated by the E2 protein in the presence of E2 binding sites.
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