ArticleProceedings of the National Academy of Sciences of the United States of America1994
Discovery of myosin genes by physical mapping in Dictyostelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains.BMC genomics · 2006Article
- Transcriptional transitions during Dictyostelium spore germination.Eukaryotic cell · 2004Article
- A millennial myosin census.Molecular biology of the cell · 2001Review
- Microsequencing of myosins for PCR primer design.Methods in molecular biology (Clifton, N.J.) · 2001Review
- How well can an amoeba climb?Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Interaptin, an actin-binding protein of the alpha-actinin superfamily in Dictyostelium discoideum, is developmentally and cAMP-regulated and associates with intracellular membrane compartments.The Journal of cell biology · 1998Article
- Dictyostelium discoideum myoJ: a member of a broadly defined myosin V class or a class XI unconventional myosin?Journal of muscle research and cell motility · 1996Article
- Ordered yeast artificial chromosome clones representing the Dictyostelium discoideum genome.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Dictyostelium mutants lacking multiple classic myosin I isoforms reveal combinations of shared and distinct functions.The Journal of cell biology · 1996Article
- Analysis of gene function in Dictyostelium.Experientia · 1995Review
- The Dictyostelium cytoskeleton.Experientia · 1995Review
- Molecular genetic analysis of myoF, a new Dictyostelium myosin I gene.Biophysical journal · 1995Article
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Authors and funding
3 authors.
Funding
Abstract
The diversity of the myosin family in a single organism, Dictyostelium discoideum, has been investigated by a strategy devised to rapidly identify and clone additional members of a gene family. An ordered array of yeast artificial chromosome clones that encompasses the Dictyostelium genome was probed at low stringency with conserved regions of the myosin motor domain to identify all possible myosin loci. The previously identified myosin loci (mchA, myoA-E) were detected by hybridization to the probes, as well as an additional seven previously unidentified loci (referred to as myoF-L). Clones corresponding to four of these additional loci (myoF, myoH-J) were obtained by using the isolated yeast artificial chromosomes as templates in a PCR employing degenerate primers specific for conserved regions of the myosin head. Sequence analysis and physical mapping of these clones confirm that these PCR products are derived from four previously unidentified myosin genes. Preliminary analysis of these sequences suggests that at least one of the genes (myoJ) encodes a member of a potentially different class of myosins. With the development of whole genome libraries for a variety of organisms, this approach can be used to rapidly explore the diversity of this and other gene families in a number of systems.
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