Evidence map›Paper›PMID 7937785›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1994

Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease.

C W Yang, H Vlassara, E P Peten, C J He, G E Striker, L J Striker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 296 citations in OpenAlex.

  1. Trial
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  3. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.Proceedings of the National Academy of Sciences of the United States of America · 2002
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  15. Stimulatory effects of advanced glycation endproducts (AGEs) on fibronectin matrix assembly.Matrix biology : journal of the International Society for Matrix Biology · 2017
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

C W YangRenal Cell Biology Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
H Vlassara
E P Peten
C J He
G E Striker
L J Striker
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

AGING &VASCULAR DISEASE ROLE OF GLYCATIONR01AG009453 · NIA · PICOWER INSTITUTE FOR MEDICAL RESEARCH · PI VLASSARA, HELEN · 1991 to 2007
$2.6M
GLYCOSYLATED PROTEINS IN AGE AND HYPERTENSIONR01AG006943 · NIA · ROCKEFELLER UNIVERSITY · PI VLASSARA, HELEN · 1987 to 1998
–
NIA NIH HHS 5 RO1 AGO9453-04NIA NIH HHS R01 AGO6943-07
6 · The paper itself

Abstract

Several lines of evidence suggest that the excessive accumulation of extracellular matrix in the glomeruli of diabetic kidneys may be due to reactive intermediates forming between glucose and matrix proteins called advanced glycation end products (AGEs). Normal mice received AGE-modified mouse serum albumin i.p. for 4 weeks, and glomerular extracellular matrix, growth factor mRNA levels, and morphology were examined. We found that AGE induced an increase in glomerular extracellular matrix alpha 1(IV) collagen, laminin B1, and transforming growth factor beta 1 mRNA levels, as measured by competitive PCR, as well as glomerular hypertrophy. The AGE response was specific because the coadministration of an AGE inhibitor, aminoguanidine, reduced all these changes. We conclude that AGEs affected expression of genes implicated in diabetic kidney disease and may play a major role in nephropathy.

Indexed as

ActinsAmino Acid SequenceAnimalsCollagenDiabetic NephropathiesDNA PrimersFemaleGene Expression RegulationGlycation End Products, AdvancedKidneyKidney GlomerulusLamininMiceMice, Inbred StrainsMolecular Sequence DataPlatelet-Derived Growth FactorActinsadvanced glycation end products-bovine serum albuminCollagenDNA PrimersGlycation End Products, AdvancedLamininPlatelet-Derived Growth FactorSerum Albumin, BovineTransforming Growth Factor beta

Identifiers

PMID7937785
PMCPMC44827
OpenAlexW2087511197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.