ArticleProceedings of the National Academy of Sciences of the United States of America1994
Identification of genes expressed in premalignant breast disease by microscopy-directed cloning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Viroimmunotherapy for Colorectal Cancer: Clinical Studies.Biomedicines · 2017Review
- Mycoplasmas and cancer: focus on nucleoside metabolism.EXCLI journal · 2014Review
- Current progress of siRNA/shRNA therapeutics in clinical trials.Biotechnology journal · 2011Review
- Identification of early molecular markers for breast cancer.Molecular cancer · 2011Article
- Detecting BRCA2 protein truncation in tissue biopsies to identify breast cancers that arise in BRCA2 gene mutation carriers.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009Article
- Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.Molecular cancer · 2009Article
- Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2.Experimental & molecular medicine · 2008Article
- The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Expression genetics in cancer: shifting the focus from DNA to RNA.Proceedings of the National Academy of Sciences of the United States of America · 1997Review
- Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Molecular analysis of premalignant and carcinoma in situ lesions of the human breast.The American journal of pathology · 1996Review
- The need for epidemiologic studies of in-situ carcinoma of the breast.Breast cancer research and treatment · 1995Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Histopathologic study of human breast biopsy samples has identified specific lesions which are associated with a high risk of development of invasive breast cancer. Presumably, these lesions (collectively termed premalignant breast disease) represent the earliest recognizable morphologic expression of fundamental molecular events that lead to the development of invasive breast cancer. To study molecular events underlying premalignant breast disease, we have developed a method for isolating RNA from histologically identified lesions from frozen human breast tissue. This method specifically obtains mRNA from breast epithelial cells and has identified three genes which are differentially expressed in premalignant breast epithelial lesions. One gene identified by this method is overexpressed in four of five noncomedo ductal carcinoma in situ lesions and appears to be the human homologue of the gene encoding the M2 subunit of ribonucleotide reductase, an enzyme involved in DNA synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.