ArticlePharmaceutical research1994
Polystyrene-poly (ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution.
Article in Pharmaceutical research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 167 citations in OpenAlex.
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- Functionalized Graphene Oxide for Chemotherapeutic Drug Delivery and Cancer Treatment: A Promising Material in Nanomedicine.International journal of molecular sciences · 2020Review
- Polymer Lung Surfactants.ACS applied bio materials · 2018Article
- Preparation and Investigation of Amphiphilic Block Copolymers/Fullerene Nanocomposites as Nanocarriers for Hydrophobic Drug.Materials (Basel, Switzerland) · 2017Article
- Branched amphiphilic peptide capsules: cellular uptake and retention of encapsulated solutes.Biochimica et biophysica acta · 2014Article
- In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers.Beilstein journal of nanotechnology · 2014Article
- Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflammasome activation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Stealth properties to improve therapeutic efficacy of drug nanocarriers.Journal of drug delivery · 2013Article
- Rational design for multifunctional non-liposomal lipid-based nanocarriers for cancer management: theory to practice.Journal of nanobiotechnology · 2013Review
- Synthesis and bioevaluation of ¹²⁵I-labeled gold nanorods.Nanotechnology · 2011Article
- Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats.International journal of pharmaceutics · 2010Article
- Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model.Anti-cancer drugs · 2010Article
- Modification of the copolymers poloxamer 407 and poloxamine 908 can affect the physical and biological properties of surface modified nanospheres.Pharmaceutical research · 1998Article
- Activation of the mononuclear phagocyte system by poloxamine 908: its implications for targeted drug delivery.Pharmaceutical research · 1997Article
- Preparation of biodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake.Pharmaceutical research · 1997Article
- Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity.British journal of cancer · 1996Article
- Formulation and antitumor activity evaluation of nanocrystalline suspensions of poorly soluble anticancer drugs.Pharmaceutical research · 1996Article
- The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres.Advanced drug delivery reviews · 1995Article
- Long-circulating emulsions (oil-in-water) as carriers for lipophilic drugs.Pharmaceutical research · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of differing densities of poly (ethylene glycol-2000) (PEG2000) at the particle surface of polystyrene-poly (ethylene glycol-2000) (PS-PEG2000) particles was assessed in terms of hydrophobic interaction chromatography (HIC) and the in vitro and in vivo behaviour of the particles. The particles, with different surface densities of PEG, were prepared by varying the copolymerizing reaction of styrene with a PEG macromonomer. There is a clear relationship between the surface density of PEG as determined by X-ray photoelectron spectroscopy and surface hydrophobicity as assessed by hydrophobic interaction chromatography (HIC). Similarly, the interaction of the particles with non-parenchymal liver cells in in vitro studies was shown to decrease as the surface density of PEG increases. The in vivo study investigating the biodistribution of the PS-PEG particles after intravenous injection into rats reveals that a relationship exists between the surface density of PEG and the extent to which the particles remain in the circulation, avoiding recognition by the reticuloendothelial system. Particles with the higher surface densities show increased circulatory times which compared well with data for particles prepared with the surface adsorbed PEO-PPO block copolymer, Poloxamine 908.
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