ReviewPostgraduate medical journal1994
Eosinophils in the 1990s: new perspectives on their role in health and disease.
Review in Postgraduate medical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 121 citations in OpenAlex.
- A Retrospective Review of 1821 Cases of Eosinophilia in a Single-Center Study in Eastern China.EJHaem · 2026Article
- Eosinophilic Patterns in Patients with Seasonal Allergy Affected by Bronchial Asthma and Rhinitis/Rhinosinusitis: Efficacy of Benralizumab in Patients with the Persistent Pattern.Journal of clinical medicine · 2024Article
- Induction of Interferon-γ and Tissue Inflammation by Overexpression of Eosinophil Cationic Protein in T Cells and Exosomes.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- The role of peripheral eosinophilia in diagnosing lung disorders: experience from a single pneumonological center.Multidisciplinary respiratory medicine · 2021Article
- Eosinopenia in COVID-19 Patients: A Retrospective Analysis.Microorganisms · 2020Article
- Mechanism of atopic cataract caused by eosinophil granule major basic protein.Medical molecular morphology · 2020Article
- Eosinopenia is a predictive factor for the severity of acute ischemic stroke.Neural regeneration research · 2019Article
- White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Observational
- The Eosinophil in Infection.Clinical reviews in allergy & immunology · 2016Review
- New Insights in Oxidant Biology in Asthma.Annals of the American Thoracic Society · 2016Review
- Warfarin-induced Eosinophilia in a Child with urkitt Lymphoma: A Case Report.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Effect of processed foods on serum levels of eosinophil cationic protein among children with atopic dermatitis.Nutrition research and practice · 2011Article
- Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite.The Journal of biological chemistry · 2010Article
- Redox control of asthma: molecular mechanisms and therapeutic opportunities.Antioxidants & redox signaling · 2010Review
- Regulation of the interleukin-5 receptor alpha-subunit on peripheral blood eosinophils from healthy subjects.Clinical and experimental immunology · 2003Article
- Caspase activation in the absence of mitochondrial changes in granulocyte apoptosis.Clinical and experimental immunology · 2002Article
- C57BL/6 mice are more susceptible to antigen-induced pulmonary eosinophilia than BALB/c mice, irrespective of systemic T helper 1/T helper 2 responses.Immunology · 1999Article
- Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation.The Journal of clinical investigation · 1999Article
- New Light Shed On The Enigmatic Eosinophil Granulocyte; A Versatile Cell Of The Immune System.EJIFCC · 1999Review
- Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents.Digestive diseases and sciences · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophils are characterized by their unique crystalloid granules that contain four basic proteins--MBP, ECP, EDN and EPO. The cell has many common features with neutrophils but, unlike that cell type, eosinophils utilize VLA-4/VCAM-1 as an adherence pathway and have a number of other receptors not shared by neutrophils. These include recognition units for IgE (distinct from CD23), and receptors for IL-5, IL-3 and RANTES. Following stimulation with a variety of agents, eosinophils preferentially elaborate LTC4 as the major 5-lipoxygenase product of arachidonic acid and produce substantial amounts of PAF. Of particular interest is the ability of eosinophils to synthesize a number of cytokines. Thus eosinophils have marked pro-inflammatory potential. There is now convincing evidence that eosinophilia is T-cell dependent. The Th2-type cell, which selectively secretes IL-5 and IL-4, seems particularly involved. IL-5, IL-3 and GM-CSF are required for eosinophil maturation, and cause activation and prolonged survival of the mature cell. IL-5 is unique in that it promotes terminal differentiation of the committed eosinophil precursor and in vivo in mice appears to be sufficient on its own for eosinophil growth from uncommited stem cells. IL-4 selectively upregulates VCAM-1 expression on endothelial cells thus augmenting VLA-4-dependent eosinophil adhesion. The role of eosinophils in disease is complex but in general their numbers are increased in helminthic parasitic disease and atopic allergy and asthma. Eosinophil products can produce many of the pathological features of asthma, and helminthic larvae coated with immunoglobulin or complement are particularly susceptible to eosinophil-mediated cytotoxicity. Eosinopenia is often related to acute inflammation or stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.