ArticleNucleic acids research1994
Bidirectional promoter of the mouse thymidylate synthase gene.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Transcriptional directionality of the human insulin-degrading enzyme promoter.Molecular and cellular biochemistry · 2013Article
- A comparative analysis of divergently-paired genes (DPGs) among Drosophila and vertebrate genomes.BMC evolutionary biology · 2009Article
- Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissues.Journal of virology · 2008Article
- Genomic organization and linkage via a bidirectional promoter of the AP-3 (adaptor protein-3) mu3A and AK (adenosine kinase) genes: deletion mutants of AK in Chinese hamster cells extend into the AP-3 mu3A gene.The Biochemical journal · 2004Article
- Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter.Journal of medical genetics · 2002Article
- Ets target genes: past, present and future.Oncogene · 2000Review
- Characterization of the TATA-less core promoter of the cell cycle-regulated cdc25C gene.Nucleic acids research · 1997Article
- Identification and characterization of a hepatitis delta virus RNA transcriptional promoter.Journal of virology · 1996Article
- Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction.Molecular and cellular biology · 1996Article
- Regulation of mouse thymidylate synthase gene expression in growth-stimulated cells: upstream S phase control elements are indistinguishable from the essential promoter elements.Nucleic acids research · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The promoter of the mouse thymidylate synthase (TS) gene lacks both a TATAA box and an initiator element and directs transcriptional initiation at multiple sites over a 90 nucleotide initiation window. Earlier studies defined an essential region near the 5' end of the initiation window that is required for promoter activity. The essential region contains possible binding sites for Sp1 and Ets transcription factors. In the present study we show that this essential region stimulates transcription with approximately equal strength in both directions. Transcription is initiated over a broad initiation window in the reverse direction. The same elements are important for the reverse promoter and for the normal TS promoter. Sequences upstream of the essential region partially suppress expression in the reverse direction. The TS 5' flanking region, in either the normal or inverted orientation, directs S phase-specific expression of a TS minigene. This raises the possibility that an upstream gene and the TS gene may be coordinately induced at the G1/S phase boundary by a common set of control elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.