ArticleMycopathologia1994
Delayed-type hypersensitivity response in an isogenic murine model of paracoccidioidomycosis.
Article in Mycopathologia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Resistance to P. brasiliensis Experimental Infection of Inbred Mice Is Associated with an Efficient Neutrophil Mobilization and Activation by Mediators of Inflammation.Mediators of inflammation · 2015Article
- B cell-deficient mice display enhanced susceptibility to Paracoccidioides brasiliensis Infection.Mycopathologia · 2013Article
- Myeloid dendritic cells (DCs) of mice susceptible to paracoccidioidomycosis suppress T cell responses whereas myeloid and plasmacytoid DCs from resistant mice induce effector and regulatory T cells.Infection and immunity · 2013Article
- In pulmonary paracoccidioidomycosis IL-10 deficiency leads to increased immunity and regressive infection without enhancing tissue pathology.PLoS neglected tropical diseases · 2013Article
- CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis.Infection and immunity · 2010Article
- Lack of galectin-3 drives response to Paracoccidioides brasiliensis toward a Th2-biased immunity.PloS one · 2009Article
- Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae).International journal of experimental pathology · 2007Article
- Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response.Infection and immunity · 2004Article
- Paracoccidioidomycosis: reduction in fungal load and abrogation of delayed-type hypersensitivity anergy in susceptible inbred mice submitted to therapy with trimethoprim-sulfamethoxazole.Medical microbiology and immunology · 2004Article
- Depletion of CD8(+) T cells in vivo impairs host defense of mice resistant and susceptible to pulmonary paracoccidioidomycosis.Infection and immunity · 2000Article
- Protective role of gamma interferon in experimental pulmonary paracoccidioidomycosis.Infection and immunity · 1998Article
- Influence of the genetic pattern and sex of mice in experimental paracoccidioidomycosis.Clinical and experimental immunology · 1995Article
- Effect of macrophage blockade on the resistance of inbred mice to Paracoccidioides brasiliensis infection.Mycopathologia · 1995Article
- Pulmonary paracoccidioidomycosis in resistant and susceptible mice: relationship among progression of infection, bronchoalveolar cell activation, cellular immune response, and specific isotype patterns.Infection and immunity · 1995Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The specific delayed-type hypersensitivity (DTH) response was evaluated in resistant (A/SN) and susceptible (B10.A) mice intraperitoneally infected with yeasts from a virulent (Pb18) or from a non-virulent (Pb265) Paracoccidioides brasiliensis isolates. Both strains of mice were footpad challenged with homologous antigens. Pb18 infected A/SN mice developed an evident and persistent DTH response late in the course of the disease (90th day on) whereas B10.A animals mounted a discrete and ephemeral DTH response at the 14th day post-infection. A/SN mice infected with Pb265 developed cellular immune responses whereas B10.A mice were almost always anergic. Histological analysis of the footpads of infected mice at 48 hours after challenge showed a mixed infiltrate consisting of predominantly mononuclear cells. Previous infection of resistant and susceptible mice with Pb18 did not alter their DTH responses against heterologous unrelated antigens (sheep red blood cells and dinitrofluorobenzene) indicating that the observed cellular anergy was antigen-specific. When fungal related antigens (candidin and histoplasmin) were tested in resistant mice, absence of cross-reactivity was noted. Thus, specific DTH responses against P. brasiliensis depend on both the host's genetically determined resistance and the virulence of the fungal isolate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.